AB7205

Anti-PAI1 antibody

Name: Anti-PAI1 antibody (ab7205) | Abcam
Brand: Abcam Limited
SKU: AB7205

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(10 Publications)

Rabbit Polyclonal PAI1 antibody. Suitable for WB and reacts with Rat samples. Cited in 10 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Serpine1.

View Alternative Names

Pai1, Planh1, Serpine1, Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1

1 Images

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Western blot - Anti-PAI1 antibody (AB7205)

Rat PAI1 detected by Western blot on Day 3 in a glomerular nephritis model.

All lanes:

Western blot - Anti-PAI1 antibody (ab7205) at 1/1000 dilution

Predicted band size: 45 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Rat Serpine1.

P20961

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 6.5 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

See full target information Serpine1

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Mediators of inflammation 2021:5599364 PubMed34456628

2021

p300/Sp1-Mediated High Expression of p16 Promotes Endothelial Progenitor Cell Senescence Leading to the Occurrence of Chronic Obstructive Pulmonary Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Zhihui He,Huaihuai Peng,Min Gao,Guibin Liang,Menghao Zeng,Xuefeng Zhang

Brazilian journal of medical and biological resear 53:e8826 PubMed32901686

2020

Decreased expression of microRNA-17 in hippocampal tissues and blood from mice with depression up-regulates the expression of PAI-1 mRNA and protein.

Applications

Unspecified application

Species

Unspecified reactive species

Min Lv,Jing Li,Xinxue Gao,Yurong Hao,Fengxia Zhao

Endocrinology 159:2621-2639 PubMed29788427

2018

Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine α-Amidating Monooxygenase.

Applications

Unspecified application

Species

Unspecified reactive species

Richard E Mains,Crysten Blaby-Haas,Bruce A Rheaume,Betty A Eipper

Experimental and therapeutic medicine 15:5125-5132 PubMed29805539

2018

MicroRNA-30b protects myocardial cell function in patients with acute myocardial ischemia by targeting plasminogen activator inhibitor-1.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Li,Jie Hu,Xingpeng Chen

Journal of cellular biochemistry 119:4692-4710 PubMed29278662

2018

MicroRNA-335-5p suppresses lower extremity deep venous thrombosis by targeted inhibition of PAI-1 via the TLR4 signalingpathway.

Applications

Unspecified application

Species

Unspecified reactive species

Cui-Xia Bao,Dong-Xia Zhang,Na-Na Wang,Xiang-Kui Zhu,Qi Zhao,Xiao-Lei Sun

FASEB journal : official publication of the Federa 29:4956-67 PubMed26405299

2015

Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-β.

Applications

Unspecified application

Species

Unspecified reactive species

Nick Hornigold,Andrew Mooney

PloS one 8:e67470 PubMed23825664

2013

NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect.

Applications

Species

Unspecified reactive species

Georgios C Stefos,Ulf Soppa,Mara Dierssen,Walter Becker

FEBS letters 586:3317-23 PubMed22819829

2012

N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Britain Abel,Cara Willoughby,Sungchan Jang,Laura Cooper,Leike Xie,Chi Vo-Ransdell,Grzegorz Sowa

The Journal of endocrinology 200:207-21 PubMed19036760

2008

Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells.

Applications

ICC, WB

Species

Mouse, Mouse

Jorge N Artaza,Keith C Norris

The Journal of endocrinology 196:235-49 PubMed18252947

2008

Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Jorge N Artaza,Rajan Singh,Monica G Ferrini,Melissa Braga,James Tsao,Nestor F Gonzalez-Cadavid

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PAI1 antibody

Western blot - Anti-PAI1 antibody (AB7205)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (10)

Product promise