Rabbit Polyclonal Cytokeratin 2P antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KRT77.
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- Frontiers in oncology 11:7607652021Measurement of Circulating Tumor Cells to Track Hepatocellular Carcinoma Progression After Liver Transplantation-Case Report.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuan Deng,Lei Sun,Heng Liang,Bojing Cui,Caimei Cui,Dan Zhao,Arabella Wan,Guohui WanPubMed 34745999
- Frontiers in oncology 11:7053842021Wnt/β-Catenin Inhibition Disrupts Carboplatin Resistance in Isogenic Models of Triple-Negative Breast Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWilly Antoni Abreu de Oliveira,Stijn Moens,Youssef El Laithy,Bernard K van der Veer,Paraskevi Athanasouli,Emanuela Elsa Cortesi,Maria Francesca Baietti,Kian Peng Koh,Juan-Jose Ventura,Frédéric Amant,Daniela Annibali,Frederic LluisPubMed 34367990
- Clinical cancer research : an official journal of the American Association for Cancer Research 27:1463-14752020Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAdriana Estrada-Bernal,Anh T Le,Andrea E Doak,Vijaya G Tirunagaru,Shevan Silva,Matthew R Bull,Jeff B Smaill,Adam V Patterson,Chul Kim,Stephen V Liu,Robert C DoebelePubMed 33355298
- Radiology and oncology 54:103-1182020Molecular heterogeneity in breast carcinoma cells with increased invasive capacities.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiulia Negro et. al.PubMed 32061169
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogens
This product was produced with the following immunogens:
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25-0.5 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Associated Products
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6 products for Alternative Product
Alternative names
KRT2B, KRT2P, KRT76, Cytokeratin-2P, Keratin-76, Type-II keratin Kb9, CK-2P, K2P, K76
Recommended products
Rabbit Polyclonal Cytokeratin 2P antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KRT77.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogens
This product was produced with the following immunogens:
- Purification technique
- Affinity purification Protein A/G
- Specificity
This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19).
- Light chain type
- kappa
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Pan cytokeratin also known as cytokeratin AE1/AE3 is a cytoskeletal protein complex that consists of different keratin polypeptides. It mechanically supports epithelial cells contributing to their structural integrity. The protein mass is variable due to its composite nature ranging between 40 to 67 kDa. Pan cytokeratin is expressed in epithelial tissues throughout the body serving as a reliable marker for identifying epithelial origin cells in histological studies.
- Biological function summary
Keratins in pan cytokeratin contribute to maintaining structural stability within epithelial cells. They act as components of the cytoskeletal network interacting with other cellular structures to provide protection from stress and mechanical damage. Pan cytokeratin exists as part of the intermediate filament protein complex which plays a significant role in cellular mechanics and cohesion essential for tissue integrity.
- Pathways
Intermediate filaments containing pan cytokeratin participate in pathways related to cell differentiation and stress response. Its interactions with other proteins like desmoplakin and plectin link the cytoskeletal filaments to cell membranes and the extracellular matrix. This involvement is important in pathways related to cellular structural integrity and epithelial-mesenchymal transition (EMT).
- Associated diseases and disorders
Pan cytokeratin serves as a critical marker in the diagnosis of epithelial-derived cancers such as carcinoma and conditions like psoriasis. Abnormal expression patterns of pan cytokeratin indicate tumor presence and origin. Its connection to proteins such as E-cadherin and vimentin assists in understanding the progression and metastasis of cancer by facilitating EMT and tissue invasion diagnostics.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody (ab217916)
Immunohistochemical analysis of formalin-fixed paraffin-embedded human skin tissue, labeling Cytokeratin using ab217916 at 0.5 μg/mL.
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