AB217916

Anti-pan Cytokeratin antibody

Lab Essentials
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(8 Publications)

Rabbit Polyclonal Cytokeratin 2P antibody. Suitable for IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KRT77.

View Alternative Names

KRT2B, KRT2P, KRT76, Cytokeratin-2P, Keratin-76, Type-II keratin Kb9, CK-2P, K2P, K76

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody (AB217916)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody (AB217916)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human skin tissue labeling Cytokeratin using ab217916 at 0.5 μg/mL.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KRT76. Database link Q01546

Specificity

This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.25-0.5 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pan cytokeratin also known as cytokeratin AE1/AE3 is a cytoskeletal protein complex that consists of different keratin polypeptides. It mechanically supports epithelial cells contributing to their structural integrity. The protein mass is variable due to its composite nature ranging between 40 to 67 kDa. Pan cytokeratin is expressed in epithelial tissues throughout the body serving as a reliable marker for identifying epithelial origin cells in histological studies.

Biological function summary

Keratins in pan cytokeratin contribute to maintaining structural stability within epithelial cells. They act as components of the cytoskeletal network interacting with other cellular structures to provide protection from stress and mechanical damage. Pan cytokeratin exists as part of the intermediate filament protein complex which plays a significant role in cellular mechanics and cohesion essential for tissue integrity.

Pathways

Intermediate filaments containing pan cytokeratin participate in pathways related to cell differentiation and stress response. Its interactions with other proteins like desmoplakin and plectin link the cytoskeletal filaments to cell membranes and the extracellular matrix. This involvement is important in pathways related to cellular structural integrity and epithelial-mesenchymal transition (EMT).

Pan cytokeratin serves as a critical marker in the diagnosis of epithelial-derived cancers such as carcinoma and conditions like psoriasis. Abnormal expression patterns of pan cytokeratin indicate tumor presence and origin. Its connection to proteins such as E-cadherin and vimentin assists in understanding the progression and metastasis of cancer by facilitating EMT and tissue invasion diagnostics.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Probably contributes to terminal cornification.

See full target information KRT76

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular and infection microbiology 15:1538461 PubMed40496014

2025

SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice.

Applications

Unspecified application

Species

Unspecified reactive species

Salmo Azambuja de Oliveira,André Acácio Souza da Silva,Barry T Hinton,Giovanni Freitas Gomes,Thiago Mattar Cunha,Paulo Sérgio Cerri,Estela Sasso-Cerri

Cancer immunology, immunotherapy : CII 74:101 PubMed39904774

2025

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanshan Yao,Chunji Chen,Bin Li,Wen Gao

Nature communications 15:9950 PubMed39550386

2024

GPRC5A promotes lung colonization of esophageal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyu Zhou,Licheng Tan,Baifeng Zhang,Dora Lai Wan Kwong,Ching Ngar Wong,Yu Zhang,Beibei Ru,Yingchen Lyu,Kin To Hugo Siu,Jie Luo,Yuma Yang,Qin Liu,Yixin Chen,Weiguang Zhang,Chaohui He,Peng Jiang,Yanru Qin,Beilei Liu,Xin-Yuan Guan

Nature communications 15:363 PubMed38191471

2024

Distinct mesenchymal cell states mediate prostate cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Hubert Pakula,Mohamed Omar,Ryan Carelli,Filippo Pederzoli,Giuseppe Nicolò Fanelli,Tania Pannellini,Fabio Socciarelli,Lucie Van Emmenis,Silvia Rodrigues,Caroline Fidalgo-Ribeiro,Pier Vitale Nuzzo,Nicholas J Brady,Wikum Dinalankara,Madhavi Jere,Itzel Valencia,Christopher Saladino,Jason Stone,Caitlin Unkenholz,Richard Garner,Mohammad K Alexanderani,Francesca Khani,Francisca Nunes de Almeida,Cory Abate-Shen,Matthew B Greenblatt,David S Rickman,Christopher E Barbieri,Brian D Robinson,Luigi Marchionni,Massimo Loda

Frontiers in oncology 11:760765 PubMed34745999

2021

Measurement of Circulating Tumor Cells to Track Hepatocellular Carcinoma Progression After Liver Transplantation-Case Report.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Deng,Lei Sun,Heng Liang,Bojing Cui,Caimei Cui,Dan Zhao,Arabella Wan,Guohui Wan

Frontiers in oncology 11:705384 PubMed34367990

2021

Wnt/β-Catenin Inhibition Disrupts Carboplatin Resistance in Isogenic Models of Triple-Negative Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Willy Antoni Abreu de Oliveira,Stijn Moens,Youssef El Laithy,Bernard K van der Veer,Paraskevi Athanasouli,Emanuela Elsa Cortesi,Maria Francesca Baietti,Kian Peng Koh,Juan-Jose Ventura,Frédéric Amant,Daniela Annibali,Frederic Lluis

Clinical cancer research : an official journal of the American Association for Cancer Research 27:1463-1475 PubMed33355298

2020

Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes.

Applications

Unspecified application

Species

Unspecified reactive species

Adriana Estrada-Bernal,Anh T Le,Andrea E Doak,Vijaya G Tirunagaru,Shevan Silva,Matthew R Bull,Jeff B Smaill,Adam V Patterson,Chul Kim,Stephen V Liu,Robert C Doebele

Radiology and oncology 54:103-118 PubMed32061169

2020

Molecular heterogeneity in breast carcinoma cells with increased invasive capacities.

Applications

Unspecified application

Species

Unspecified reactive species

Giulia Negro,Bertram Aschenbrenner,Simona Kranjc Brezar,Maja Cemazar,Andrej Coer,Gorana Gasljevic,Dragana Savic,Maxim Sorokin,Anton Buzdin,Maurizio Callari,Irma Kvitsaridze,Anahid Jewett,Mariela Vasileva-Slaveva,Ute Ganswindt,Ira Skvortsova,Sergej Skvortsov

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