Mouse Multiclonal Cytokeratin 1 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Rat, Fish, Zebrafish, Chicken, Human, Dog, Cat, Cow, Rabbit samples. Cited in 42 publications.
| IHC-P | ICC/IF | |
|---|---|---|
| Human | Expected | Expected |
| Mouse | Expected | Expected |
| Rat | Expected | Expected |
| Cat | Expected | Expected |
| Chicken | Expected | Expected |
| Cow | Expected | Expected |
| Dog | Expected | Expected |
| Fish | Expected | Expected |
| Rabbit | Expected | Expected |
| Zebrafish | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Fish, Zebrafish, Chicken, Human, Dog, Cat, Cow, Rabbit | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Fish, Zebrafish, Chicken, Human, Dog, Cat, Cow, Rabbit | Dilution info Use at an assay dependent concentration. | Notes - |
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May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
KRT16, Keratin, type I cytoskeletal 14, Keratin, type I cytoskeletal 9, KRT17, KRT4, KRT2, Keratin, type II cytoskeletal 5, Keratin, type I cytoskeletal 13, KRT6A, KRT12, KRT3, KRT10, KRT15
KRTA, KRT1, 67 kDa cytokeratin, Cytokeratin-1, Hair alpha protein, Keratin-1, Type-II keratin Kb1, CK-1, K1
Mouse Multiclonal Cytokeratin 1 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Rat, Fish, Zebrafish, Chicken, Human, Dog, Cat, Cow, Rabbit samples. Cited in 42 publications.
This antibody mixture recognizes acidic and basic subfamilies of cytokeratins. The cocktail of these two antibodies can be used to detect most human epithelia. The acidic cytokeratins have molecular weights of 56.5, 55, 51, 50, 50, 48 46, 45, and 40 kDa. The basic cytokeratins have molecular weights of 65-67, 64, 59, 58, 56 and 52 kDa.
This product was changed from ascites to tissue culture supernatant on 8th March 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
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Please note that this antibody is an oligoclonal antibody. It is a cocktail of monoclonal antibodies that have been carefully selected. Oligoclonal antibodies have not only the specificity and batch-to-batch consistency of a monoclonal antibody, but also have the advantage of the sensitivity of a polyclonal antibody due to their ability to recognize multiple epitopes on an antigen.
Pan cytokeratin also known as cytokeratin AE1/AE3 is a cytoskeletal protein complex that consists of different keratin polypeptides. It mechanically supports epithelial cells contributing to their structural integrity. The protein mass is variable due to its composite nature ranging between 40 to 67 kDa. Pan cytokeratin is expressed in epithelial tissues throughout the body serving as a reliable marker for identifying epithelial origin cells in histological studies.
Keratins in pan cytokeratin contribute to maintaining structural stability within epithelial cells. They act as components of the cytoskeletal network interacting with other cellular structures to provide protection from stress and mechanical damage. Pan cytokeratin exists as part of the intermediate filament protein complex which plays a significant role in cellular mechanics and cohesion essential for tissue integrity.
Intermediate filaments containing pan cytokeratin participate in pathways related to cell differentiation and stress response. Its interactions with other proteins like desmoplakin and plectin link the cytoskeletal filaments to cell membranes and the extracellular matrix. This involvement is important in pathways related to cellular structural integrity and epithelial-mesenchymal transition (EMT).
Pan cytokeratin serves as a critical marker in the diagnosis of epithelial-derived cancers such as carcinoma and conditions like psoriasis. Abnormal expression patterns of pan cytokeratin indicate tumor presence and origin. Its connection to proteins such as E-cadherin and vimentin assists in understanding the progression and metastasis of cancer by facilitating EMT and tissue invasion diagnostics.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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