Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297) is a rabbit monoclonal antibody that is used to detect pan Cytokeratin in IHC-P. Suitable for Human samples.
Images
![Immunocytochemistry - Anti-pan Cytokeratin antibody [KRT/1877R] (AB234297), expandable thumbnail](https://content.abcam.com/products/images/pan-cytokeratin-antibody-krt-1877r-ab234297--immunocytochemistry-img166484.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry - Anti-pan Cytokeratin antibody [KRT/1877R] (AB234297)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody [KRT/1877R] (AB234297), expandable thumbnail](https://content.abcam.com/products/images/pan-cytokeratin-antibody-krt-1877r-ab234297--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img114683.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody [KRT/1877R] (AB234297)")
Publications
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- iScience 26:1078942023An immunosuppressive subtype of senescent tumor cells predicted worse immunotherapy response in lung adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuangyu Fan,Tongji Xie,Qiaoyun Tan,Ning Lou,Shasha Wang,Xiaohong Han,Yuankai ShiPubMed 37766998
- Journal of the European Academy of Dermatology and Venereology : JEADV 37:1920-19272023Interleukin-37 inhibits desmoglein-3 endocytosis and keratinocyte dissociation via upregulation of Caveolin-1 and inhibition of the STAT3 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJunqin Liang,Fengxia Hu,Lidan Mao,Yun Qiu,Fanhe Jiang,Qian Wang,Kailibinuer Abulikemu,Yongzhen Hong,Xinyu Ge,Xiaojing KangPubMed 37262304
- BMC cancer 22:4232022Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHyuk Moon,Hyunjung Park,Min Jee Chae,Hye Jin Choi,Do Young Kim,Simon Weonsang RoPubMed 35439973
- Experimental and therapeutic medicine 22:8282021MEF/KSF-conditioned culture medium: An effective method for culture of mouse dermal papilla cells with osteogenic differentiation potential.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiang Xu,Wenlan Gao,Shanshan Bai,Huichuan Duan,Xiaogang Pan,Wei WuPubMed 34149874
- Nature medicine 27:892-9032021SARS-CoV-2 infection of the oral cavity and saliva.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNi Huang,Paola Pérez,Takafumi Kato,Yu Mikami,Kenichi Okuda,Rodney C Gilmore,Cecilia Domínguez Conde,Billel Gasmi,Sydney Stein,Margaret Beach,Eileen Pelayo,Jose O Maldonado,Bernard A Lafont,Shyh-Ing Jang,Nadia Nasir,Ricardo J Padilla,Valerie A Murrah,Robert Maile,William Lovell,Shannon M Wallet,Natalie M Bowman,Suzanne L Meinig,Matthew C Wolfgang,Saibyasachi N Choudhury,Mark Novotny,Brian D Aevermann,Richard H Scheuermann,Gabrielle Cannon,Carlton W Anderson,Rhianna E Lee,Julie T Marchesan,Mandy Bush,Marcelo Freire,Adam J Kimple,Daniel L Herr,Joseph Rabin,Alison Grazioli,Sanchita Das,Benjamin N French,Thomas Pranzatelli,John A Chiorini,David E Kleiner,Stefania Pittaluga,Stephen M Hewitt,Peter D Burbelo,Daniel Chertow,Karen Frank,Janice Lee,Richard C Boucher,Sarah A Teichmann,Blake M Warner,Kevin M ByrdPubMed 33767405
- medRxiv : the preprint server for health sciences :2020Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNi Huang,Paola Perez,Takafumi Kato,Yu Mikami,Kenichi Okuda,Rodney C Gilmore,Cecilia Domínguez Conde,Billel Gasmi,Sydney Stein,Margaret Beach,Eileen Pelayo,Jose Maldonado,Bernard LaFont,Ricardo Padilla,Valerie Murrah,Robert Maile,Will Lovell,Shannon Wallet,Natalie M Bowman,Suzanne L Meinig,Matthew C Wolfgang,Saibyasachi N Choudhury,Mark Novotny,Brian D Aevermann,Richard Scheuermann,Gabrielle Cannon,Carlton Anderson,Julie Marchesan,Mandy Bush,Marcelo Freire,Adam Kimple,Daniel L Herr,Joseph Rabin,Alison Grazioli,Benjamin N French,Thomas Pranzatelli,John A Chiorini,David E Kleiner,Stefania Pittaluga,Stephen Hewitt,Peter D Burbelo,Daniel Chertow,Karen Frank,Janice Lee,Richard C Boucher,Sarah A Teichmann,Blake M Warner,Kevin M ByrdPubMed 33140061
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Cell preparation containing pan Cytokeratin protein. The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IHC-P | ICC | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
| Cow | Predicted | Predicted |
| Goat | Predicted | Predicted |
| Guinea pig | Predicted | Predicted |
| Monkey | Predicted | Predicted |
| Pig | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.50000-1.00000 µg/mL | Notes Primary incubation for 30 minutes at room temperature. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Goat, Guinea pig, Cow, Pig, Monkey | Dilution info - | Notes - |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-2.00000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Goat, Guinea pig, Cow, Pig, Monkey | Dilution info - | Notes - |
Associated Products
Select an associated product type
6 products for Alternative Product
1 product for Alternative Version
Target data
Alternative names
pan-ck
Recommended products
Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297) is a rabbit monoclonal antibody that is used to detect pan Cytokeratin in IHC-P. Suitable for Human samples.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Cell preparation containing pan Cytokeratin protein. The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- KRT/1877R
- Purification technique
- Affinity purification Protein A/G
- Concentration
- Purification notes
Purified from Bioreactor Concentrate by Protein A/G.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297) is a rabbit monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.
Reviewed by scientists
Anti-pan Cytokeratin [KRT/1877R] (ab234297) has over 5 independent reviews from customers.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Pan cytokeratin also known as cytokeratin AE1/AE3 is a cytoskeletal protein complex that consists of different keratin polypeptides. It mechanically supports epithelial cells contributing to their structural integrity. The protein mass is variable due to its composite nature ranging between 40 to 67 kDa. Pan cytokeratin is expressed in epithelial tissues throughout the body serving as a reliable marker for identifying epithelial origin cells in histological studies.
- Biological function summary
Keratins in pan cytokeratin contribute to maintaining structural stability within epithelial cells. They act as components of the cytoskeletal network interacting with other cellular structures to provide protection from stress and mechanical damage. Pan cytokeratin exists as part of the intermediate filament protein complex which plays a significant role in cellular mechanics and cohesion essential for tissue integrity.
- Pathways
Intermediate filaments containing pan cytokeratin participate in pathways related to cell differentiation and stress response. Its interactions with other proteins like desmoplakin and plectin link the cytoskeletal filaments to cell membranes and the extracellular matrix. This involvement is important in pathways related to cellular structural integrity and epithelial-mesenchymal transition (EMT).
- Associated diseases and disorders
Pan cytokeratin serves as a critical marker in the diagnosis of epithelial-derived cancers such as carcinoma and conditions like psoriasis. Abnormal expression patterns of pan cytokeratin indicate tumor presence and origin. Its connection to proteins such as E-cadherin and vimentin assists in understanding the progression and metastasis of cancer by facilitating EMT and tissue invasion diagnostics.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
![Immunocytochemistry - Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297), expandable thumbnail](https://content.abcam.com/products/images/pan-cytokeratin-antibody-krt-1877r-ab234297--immunocytochemistry-img166484.jpg "Immunocytochemistry - Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297)")
Immunocytochemistry - Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297)
Immunocytochemistry analysis of MCF7 cells labeling pan Cytokeratin with ab234297 at 2ug/mL followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297), expandable thumbnail](https://content.abcam.com/products/images/pan-cytokeratin-antibody-krt-1877r-ab234297--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img114683.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan Cytokeratin antibody [KRT/1877R] (ab234297)
Formalin-fixed, paraffin-embedded human skin tissue stained for pan Cytokeratin using ab234297 at 1 μg/ml in immunohistochemical analysis.
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