JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB228737

Anti-Pancreatic Lipase/PTL antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Pancreatic Lipase/PTL antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PNLIP.

View Alternative Names

Pancreatic triacylglycerol lipase, PL, PTL, Pancreatic lipase, PNLIP

1 Images
Western blot - Anti-Pancreatic Lipase/PTL antibody (AB228737)
  • WB

Supplier Data

Western blot - Anti-Pancreatic Lipase/PTL antibody (AB228737)

10% SDS-PAGE gel.

All lanes:

Western blot - Anti-Pancreatic Lipase/PTL antibody (ab228737) at 1/5000 dilution

All lanes:

Mouse pancreas tissue extract at 30 µg

Predicted band size: 51 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PNLIP. The exact immunogen used to generate this antibody is proprietary information.

P16233

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pancreatic Lipase also known as PTL or Lipase Pancreas is an enzyme with a molecular mass around 3000 daltons. It is important for the digestion of dietary fats and is expressed in the pancreas of several animals including the mouse and rat. The enzyme hydrolyzes triglycerides into monoglycerides and free fatty acids facilitating the absorption of fat-soluble vitamins. The presence of pancreatic lipase in rodent models like 'pancreas in rat' or 'mouse pancreas' aids in studying its mechanical function which is significant for understanding lipid metabolism.
Biological function summary

Pancreatic lipase plays a central role in the digestive system converting dietary fats into absorbable units. Although primarily not part of any complex its activity depends on the presence of bile salts and co-lipase. Co-lipase binds to pancreatic lipase and enhances its efficiency by stabilizing the enzyme-substrate complex in the presence of bile supporting lipid digestion and absorption.

Pathways

The enzyme is an essential component of the lipid digestion and absorption pathways. It operates closely with other lipases like gastric lipase sequentially breaking down fats from different stages of digestion. The pathways involve the secretion of bile from the liver which emulsifies fats enabling pancreatic lipase to act more efficiently. As part of the larger digestion process the enzyme plays a role in maintaining metabolic homeostasis by interlinking with hormones like insulin which further regulates blood glucose levels based on energy intake from fats.

Pancreatic lipase has significant implications in conditions like hyperlipidemia and pancreatitis. Defects or deficiencies in pancreatic lipase activity can result in malabsorption syndromes affecting nutritional status and leading to weight loss and vitamin deficiencies. Chronic pancreatitis an inflammatory disease with progressive exocrine pancreatic insufficiency involves diminished pancreatic lipase function often requiring enzyme supplementation as part of the treatment. The connection of pancreatic lipase to hyperlipidemia relates to its interaction with proteins like lipoprotein lipase which manages lipid levels within the bloodstream.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
See full target information PNLIP
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular biosciences 8:683267 PubMed34422900

2021

Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Caijuan Huan,Wangting Xu,Yaru Liu,Kexin Ruan,Yueli Shi,Hongqiang Cheng,Xue Zhang,Yuehai Ke,Jianying Zhou
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB96100

Anti-Pancreatic Lipase/PTL antibody

Immunocytochemistry/ Immunofluorescence - Anti-Pancreatic Lipase/PTL antibody (AB96100)

  • 0
  • 0
Primary Antibodies

AB198181

Anti-Pancreatic Lipase/PTL antibody

Western blot - Anti-Pancreatic Lipase/PTL antibody (AB198181)

  • 0
  • 0
Primary Antibodies

AB124915

Anti-Pancreatic Lipase/PTL antibody [EPR6276]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pancreatic Lipase/PTL antibody [EPR6276] (AB124915)

  • 0
  • 0
Primary Antibodies

AB133556

Anti-Pancreatic Lipase/PTL antibody [EPR6275]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pancreatic Lipase/PTL antibody [EPR6275] (AB133556)

  • 0
  • 0

Complementary Products

Assay Kits

AB102524

Lipase Assay Kit (Colorimetric)

Functional Studies - Lipase Assay Kit (Colorimetric) (AB102524)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB271132

Anti-Prealbumin antibody [EPR24246-14]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prealbumin antibody [EPR24246-14] (AB271132)

  • 0
  • 0
Primary Antibodies

AB228776

Anti-TMPRSS11D antibody

Western blot - Anti-TMPRSS11D antibody (AB228776)

  • 0
  • 0
Primary Antibodies

AB200997

Anti-Trypsin antibody [EPR19498-43]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Trypsin antibody [EPR19498-43] (AB200997)

  • 5
  • 2

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com