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Rabbit Polyclonal Pancreatic Polypeptide antibody. Suitable for WB and reacts with Human, Transfected cell lysate - Human samples. Immunogen corresponding to Synthetic Peptide within Human PPY.

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Images

Western blot - Anti-Pancreatic Polypeptide antibody (AB229322), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human PPY. The exact immunogen used to generate this antibody is proprietary information. Database link P01298

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Rhesus monkey
Predicted
Transfected cell lysate - Human
Tested

Tested
Tested

Species

Human

Dilution info

1/5000.00000 - 1/20000.00000

Notes

-

Species

Transfected cell lysate - Human

Dilution info

1/5000.00000 - 1/20000.00000

Notes

-

Predicted
Predicted

Species

Rhesus monkey

Dilution info

-

Notes

-

Associated Products

Select an associated product type

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Target data

Function

Pancreatic polypeptideHormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2.

Targets

Pancreatic Polypeptide

Alternative names

Recommended products

Rabbit Polyclonal Pancreatic Polypeptide antibody. Suitable for WB and reacts with Human, Transfected cell lysate - Human samples. Immunogen corresponding to Synthetic Peptide within Human PPY.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human PPY. The exact immunogen used to generate this antibody is proprietary information. Database link P01298
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Pancreatic Polypeptide also known as PP is a small protein with a molecular mass approximately 4200 Da. It is secreted by PP cells in the pancreas particularly in the F-cells located in the Langerhans islets. This peptide is highly conserved among different species including the rat where it displays similar function and expression patterns. Pancreatic polypeptide regulates various physiological processes by binding to specific receptors on target tissues.

Biological function summary

In various mammalian species including rats pancreatic polypeptide plays a significant role in the regulation of appetite and pancreatic secretion. It is not recognized as part of a multi-protein complex but it directly influences the function of digestive organs by inhibiting pancreatic exocrine secretions and gallbladder contraction. This makes it an important mediator in controlling the body's energy balance and digestive functions.

Pathways

Pancreatic polypeptide is involved in the peptidergic pathway regulating energy homeostasis and digestive processes. It interacts with the Y receptor family particularly the Y4 receptor which contributes to its regulatory actions on appetite and digestive enzyme secretion. This peptide works alongside other polypeptides such as neuropeptide Y and peptide YY in mediating these complex physiological pathways.

Associated diseases and disorders

Pancreatic polypeptide levels relate to conditions such as obesity and diabetes. Altered secretion of this peptide can contribute to obesity by affecting appetite regulation and energy homeostasis. Furthermore in diabetes pancreatic polypeptide is connected to abnormal pancreatic function often observed alongside insulin and glucagon dysregulation. Understanding these relationships can provide insight into therapeutic strategies targeting metabolic and endocrine disorders.

Product promise

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1 product image

  • Western blot - Anti-Pancreatic Polypeptide antibody (ab229322), expandable thumbnail

    Western blot - Anti-Pancreatic Polypeptide antibody (ab229322)

    15% SDS-PAGE gel.

    All lanes: Western blot - Anti-Pancreatic Polypeptide antibody (ab229322) at 1/10000 dilution

    Lane 1: Non-transfected HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate/extract at 30 µg

    Lane 2: Pancreatic Polypeptide-transfected HEK-293T whole cell lysate/extract at 30 µg

    Developed using the ECL technique.

    Predicted band size: 10 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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