Anti-Pannexin 1 antibody [RP23040037]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Pannexin 1 also known as PANX1 is a membrane channel protein with a mass of approximately 48 kDa. This protein functions as an important part of the cellular communication system by forming channels that facilitate the release of ATP and other signaling molecules from the cytoplasm to the extracellular space. It is widely expressed across various tissues including the central nervous system skin and muscles. Pannexin-1 is often found on the cell surface where it operates in coordination with other cellular components to regulate intercellular interactions and signaling networks.

Biological function summary

Pannexin 1 plays a significant role in various physiological processes such as inflammation apoptosis and synaptic plasticity. It forms part of large multiprotein complexes that can include connexins and other ion channels. Through these complexes pannexin 1 helps mediate the flow of ions and small molecules across the cell membrane influencing cellular responses and communication. The ATP release mediated by pannexin-1 channels is particularly involved in activating purinergic receptors on neighboring cells contributing to diverse cellular responses.

Pathways

Pannexin 1 participates actively in the purinergic signaling pathway where it plays a role in ATP mediated communication between cells. This protein also integrates into the inflammasome pathway impacting inflammation and immune responses. Within these pathways pannexin-1 interacts with proteins such as P2X7 receptors which are essential for the activation of specific signaling cascades linked to these biological processes. The interaction with other channels like connexins enhances its regulatory role in physiological functions.

Associated diseases and disorders

Pannexin 1 has been implicated in the pathophysiology of conditions such as epilepsy and skin disorders. Its ability to control ATP release and consequently influence neuron excitability relates significantly to the onset and progression of epilepsy. PANX1 also interacts with cytokines in skin cells where dysregulation can contribute to inflammatory skin conditions. Additionally alterations in pannexin-1 function and expression have connections to changes in P2X7 receptor activities linking it to both neurological and dermatological disease pathways.