Rabbit Polyclonal PAR4 antibody. Suitable for WB and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human PAWR aa 300 to C-terminus.
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Publications
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- The American journal of pathology 192:361-3782022Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDevin Cao,Michael G Strainic,Daniel Counihan,Shiva Sridar,Fengqi An,Wasim Hussain,Alvin H Schmaier,Marvin Nieman,M Edward MedofPubMed 35144762
- Scientific reports 9:87552019PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaihong Guo et. al.PubMed 31217499
- Human molecular genetics 20:1610-242011A complex regulatory network of transcription factors critical for ocular development and disease.Applications:IPReactive species:Unspecified reactive speciesMoulinath Acharya et. al.PubMed 21282189
- The Journal of biological chemistry 284:34829-382009Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells.
- Proceedings of the National Academy of Sciences of 106:12962-72009Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.
- The Journal of endocrinology 194:77-852007IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHyunju Chung,Sanghee Seo,Minho Moon,Seungjoon ParkPubMed 17592023
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human PAWR aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q96IZ0
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Reactivity data
Select an application| WB | |
|---|---|
| Rat | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 2 µg/mL | Notes - |
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Target data
Function
Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Alternative names
PAR4, PAWR, PRKC apoptosis WT1 regulator protein, Prostate apoptosis response 4 protein, Par-4
Recommended products
Rabbit Polyclonal PAR4 antibody. Suitable for WB and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human PAWR aa 300 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human PAWR aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q96IZ0
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-PAR4 antibody (ab5787)
All lanes: Western blot - Anti-PAR4 antibody (ab5787)
All lanes: Rat spleen extract
Predicted band size: 37 kDa
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