AB5787

Anti-PAR4 antibody

Name: Anti-PAR4 antibody (ab5787) | Abcam
Brand: Abcam Limited
SKU: AB5787

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(7 Publications)

Rabbit Polyclonal PAR4 antibody. Suitable for WB and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human PAWR aa 300 to C-terminus.

View Alternative Names

PAR4, PAWR, PRKC apoptosis WT1 regulator protein, Prostate apoptosis response 4 protein, Par-4

1 Images

Supplier Data

Western blot - Anti-PAR4 antibody (AB5787)

All lanes:

Western blot - Anti-PAR4 antibody (ab5787)

All lanes:

Rat spleen extract

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Synthetic Peptide within Human PAWR aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96IZ0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

See full target information PAWR

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40141421

2025

PAR Serves an Indispensable Role in Controlling PAR Oncogenicity: The β-Catenin-p53 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Priyanga Appasamy,Jeetendra Kumar Nag,Hodaya Malka,Rachel Bar-Shavit

The American journal of pathology 192:361-378 PubMed35144762

2022

Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Devin Cao,Michael G Strainic,Daniel Counihan,Shiva Sridar,Fengqi An,Wasim Hussain,Alvin H Schmaier,Marvin Nieman,M Edward Medof

Scientific reports 9:8755 PubMed31217499

2019

PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1.

Applications

Unspecified application

Species

Unspecified reactive species

Haihong Guo,Fabian Treude,Oliver H Krämer,Bernhard Lüscher,Jörg Hartkamp

Human molecular genetics 20:1610-24 PubMed21282189

2011

A complex regulatory network of transcription factors critical for ocular development and disease.

Applications

Species

Unspecified reactive species

Moulinath Acharya,Lijia Huang,Valerie C Fleisch,W Ted Allison,Michael A Walter

The Journal of biological chemistry 284:34829-38 PubMed19801652

2009

Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells.

Applications

IHC-P, IHC-P, WB, WB

Species

Human, Mouse, Human, Mouse

Moulinath Acharya,David J Lingenfelter,Lijia Huang,Philip J Gage,Michael A Walter

Proceedings of the National Academy of Sciences of 106:12962-7 PubMed19470463

2009

Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.

Applications

IHC-P

Species

Human

Pablo J Fernandez-Marcos,Shadi Abu-Baker,Jayashree Joshi,Anita Galvez,Elias A Castilla,Marta Cañamero,Manuel Collado,Carmen Saez,Gema Moreno-Bueno,Jose Palacios,Michael Leitges,Manuel Serrano,Jorge Moscat,Maria T Diaz-Meco

The Journal of endocrinology 194:77-85 PubMed17592023

2007

IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.

Applications

Unspecified application

Species

Unspecified reactive species

Hyunju Chung,Sanghee Seo,Minho Moon,Seungjoon Park

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PAR4 antibody

Western blot - Anti-PAR4 antibody (AB5787)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (7)

Product promise