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AB20791

Anti-Parainfluenza Virus type 1 antibody

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(1 Publication)

Goat Polyclonal Parainfluenza Virus type 1 antibody. Suitable for ELISA and reacts with Human respirovirus 1 samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Parainfluenza Virus type 1 protein.

View Alternative Names

HPIV 1, Human parainfluenza 1 virus, Human parainfluenza virus type, Parainfluenza, Parainfluenza Type 1

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human respirovirus 1

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Parainfluenza 1, all structural antigens.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Ion exchange chromatography
Purification notes
>95% pure. Sodium sulfate precipitation and ion-exchange chromatography.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Parainfluenza Virus type 1 also known as Human Parainfluenza Virus 1 (HPIV-1) is an enveloped single-stranded RNA virus belonging to the family Paramyxoviridae. It plays an important role in respiratory tract infections and has a mass estimated around 15-18 kilobases. HPIV-1 primarily expresses its proteins in the epithelial cells of the respiratory tract where it facilitates viral replication and spread. Key surface proteins include hemagglutinin-neuraminidase (HN) and fusion protein (F) which assist in viral attachment and entry into host cells.
Biological function summary

Parainfluenza Virus type 1 affects the mucosa of the upper and lower respiratory tract leading to conditions such as croup in children. It is not part of a larger complex but functions independently to hijack host cellular machinery for replication. The HN protein binds to sialic acid-containing receptors on the host cell surface while the F protein enables the merging of viral and cellular membranes a process essential for viral entry.

Pathways

The mechanics of Parainfluenza Virus type 1 integrate into immune evasion and viral propagation pathways. The virus down-regulates the host's interferon response which is critical for antiviral activity. Proteins like the V protein interact with host signaling molecules to inhibit interferon production ensuring virus survival. This interaction connects HPIV-1 to essential immune regulation pathways influencing antiviral responses.

Parainfluenza Virus type 1 is notably associated with respiratory diseases such as croup and bronchiolitis. These disorders result from the virus's ability to induce inflammation and mucus production in the airway. The F protein of HPIV-1 contributes to the fusion of infected cells forming syncytia which exacerbate respiratory symptoms. This viral mechanism highlights the virus's potential impact on respiratory health and the body's response to infection.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Parainfluenza Virus type 1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 91: PubMed28250127

2017

Attenuated Human Parainfluenza Virus Type 1 Expressing Ebola Virus Glycoprotein GP Administered Intranasally Is Immunogenic in African Green Monkeys.

Applications

Unspecified application

Species

Unspecified reactive species

Matthias Lingemann,Xueqiao Liu,Sonja Surman,Bo Liang,Richard Herbert,Ashley D Hackenberg,Ursula J Buchholz,Peter L Collins,Shirin Munir
View all publications
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Product promise

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