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AB252769

Anti-Parainfluenza Virus Type 3 Hemagglutinin antibody [B289M]

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(1 Publication)

Mouse Monoclonal HN antibody. Suitable for ELISA and reacts with Human respirovirus 3 samples. Cited in 1 publication.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

B289M

Isotype

IgG2a

Carrier free

No

Reacts with

Human respirovirus 3

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human respirovirus 3": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
>90% (SDS-PAGE). Sourced from Tissue Culture Supernatant.
Storage buffer
Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Parainfluenza Virus Type 3 Hemagglutinin also called HA3 facilitates the virus's entry into host cells. It binds to sialic acid on the cell surface starting the infection process. This protein approximately 60 kDa in mass is integral to the viral envelope where it forms spikes. Expression occurs predominantly in the envelope of Parainfluenza Virus Type 3 organisms essential for its function in attachment and subsequent fusion to host cells.
Biological function summary

This hemagglutinin mediates attachment and fusion of the virus with host cell membranes. It serves as an important component of the envelope glycoprotein complex collaborating with other viral proteins to promote efficient host cell entry. By facilitating membrane fusion the hemagglutinin enables the transfer of viral RNA into the host cell setting the stage for viral replication and propagation within the host.

Pathways

Parainfluenza Virus Type 3 Hemagglutinin takes part in the viral entry pathway. It closely interacts with the fusion protein F another important viral envelope protein to execute successful membrane fusion. Together they ensure the release of viral RNA making it a vital part of the viral infection and replication cycle. Understanding these interactions can provide insights into viral propagation mechanisms and potential targets for intervention.

Parainfluenza Virus Type 3 Hemagglutinin is primarily associated with respiratory illnesses such as bronchiolitis and pneumonia. It plays a significant role in the pathogenesis of these conditions by facilitating viral invasion in respiratory epithelial cells. The hemagglutinin's interaction with host proteins is critical in initiating infection highlighting its potential as a therapeutic target for reducing disease severity and transmission.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Current protocols 4:e1030 PubMed38923763

2024

Applications of Surface Plasmon Resonance (SPR) to the Study of Diverse Protein-Ligand Interactions.

Applications

Unspecified application

Species

Unspecified reactive species

Dana M Burris,Samuel W Gillespie,Emma Joy Campbell,S Nick Ice,Vikas Yadav,William D Picking,Christian L Lorson,Kamal Singh
View all publications

Product promise

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