AB234739

Anti-Paralemmin-1 antibody

Name: Anti-Paralemmin-1 antibody (ab234739) | Abcam
Brand: Abcam Limited
SKU: AB234739
Price: 525 USD
Availability: InStock

Be the first to review this product! Submit a review

(2 Publications)

Rabbit Polyclonal Paralemmin-1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PALM.

View Alternative Names

KIAA0270, PALM, Paralemmin-1, Paralemmin

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Paralemmin-1 antibody (AB234739)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Paralemmin-1 antibody (AB234739)

Paraffin-embedded human brain tissue stained for Paralemmin-1 with ab234739 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Paralemmin-1 antibody (AB234739)

Paraffin-embedded human kidney tissue stained for Paralemmin-1 with ab234739 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-Paralemmin-1 antibody (AB234739)

All lanes:

Western blot - Anti-Paralemmin-1 antibody (ab234739) at 1/500 dilution

All lanes:

Mouse kidney tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 42 kDa

Observed band size: 43 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PALM.

O75781

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Paralemmin-1 also known as PALM is a lipid-anchored protein linked to the plasma membrane and involved in cellular processes that regulate cell shape and plasticity. It has a molecular weight of approximately 42 kDa. This protein expresses mainly in the brain particularly in regions like the hippocampus suggesting its significant role in neural cell function. Some data also note its presence in other tissues like the kidney and testis but at much lower levels compared to neural tissue.

Biological function summary

Paralemmin-1 plays a role in cellular membrane dynamics and structure. It assists in the stabilization of filopodia and participates in the regulation of neurite outgrowth both critical in neural development and maintenance. Although not a well-defined complex member Paralemmin-1 interacts with other proteins involved in cytoskeletal reorganization highlighting its importance in cellular morphology.

Pathways

Some studies point out that Paralemmin-1 associates with signaling cascades controlling actin cytoskeleton rearrangement particularly the Rho GTPase pathway. This protein interfaces with small GTPases like Cdc42 or Rac1 that drive changes in cell shape and motility directly linking it to the regulation of actin dynamics. Such interactions highlight its involvement in pathways integral to cell structure and signaling.

Deficits in Paralemmin-1 function have correlations with neurological disorders such as autism spectrum disorders (ASD) and intellectual disability. Pathologies like these show altered neuronal connectivity and synaptic plasticity areas where Paralemmin-1's role becomes important through its interaction with proteins like synaptic adhesion molecules. These associations point to Paralemmin-1 as a potential target for understanding and possibly modifying the progression of these neurological conditions.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.

See full target information PALM

style

left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37298594

2023

Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Wang,Yu Wang,Ana Montero-Pedrazuela,Lucía Prensa,Ana Guadaño-Ferraz,Estrella Rausell

Frontiers in cellular neuroscience 15:662035 PubMed34025359

2021

Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1.

Applications

Unspecified application

Species

Unspecified reactive species

Anchel González-Barriga,Louison Lallemant,Diana M Dincã,Sandra O Braz,Hélène Polvèche,Paul Magneron,Cédric Pionneau,Aline Huguet-Lachon,Jean-Baptiste Claude,Cerina Chhuon,Ida Chiara Guerrera,Cyril F Bourgeois,Didier Auboeuf,Geneviève Gourdon,Mário Gomes-Pereira

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Paralemmin-1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Paralemmin-1 antibody (AB234739)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Paralemmin-1 antibody (AB234739)

Western blot - Anti-Paralemmin-1 antibody (AB234739)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise