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AB33637

Anti-Paramyxovirus Type 3 antibody

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(1 Publication)

Chicken Polyclonal Paramyxovirus Type 3 antibody. Suitable for ELISA and reacts with Paramyxovirus sp. samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Paramyxovirus Type 3 protein.

Key facts

Host species

Chicken

Clonality

Polyclonal

Isotype

IgY

Carrier free

No

Reacts with

Paramyxovirus sp.

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

This antibody is monospecific.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Paramyxovirus sp.": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Purification notes
This antibody is a sterile filtered serum produced in SPF (Specific Pathogen Free) chicken embryos.
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Add glycerol to a final volume of 50% for extra stability and aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Paramyxovirus Type 3 also known as human parainfluenza virus type 3 (HPIV3) is a member of the Paramyxoviridae family. This virus exhibits a genome composed of negative-sense single-stranded RNA and encodes six structural proteins. The virus particle measures approximately 150-250 nm in diameter and possesses a lipid envelope. HPIV3 is expressed in respiratory epithelial cells and is responsible for significant respiratory tract infections.
Biological function summary

The virus targets epithelial cells in the human respiratory tract causing cellular damage and inflammation. HPIV3 uses surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion (F) protein to facilitate the attachment and fusion with host cells. These proteins form part of a complex responsible for host cell entry and viral replication. The fusion protein with a molecular weight of approximately 60 kDa is instrumental in the fusion process.

Pathways

Several other molecules play an important role in HPIV3's replication cycle. HPIV3 initiates the host cell entry pathway using attachment to the sialic acid receptors on the host cell surface via its HN protein. Its interaction in the fusion pathway is essential for virus entry and replicative cycle continuation. The fusion pathway resembles that of other paramyxoviruses like the respiratory syncytial virus (RSV) which also relies on surface glycoproteins for cell entry.

HPIV3 is linked to respiratory illnesses such as bronchiolitis and pneumonia especially in young children and immunocompromised individuals. The viral infection increases pro-inflammatory cytokines in the host exacerbating respiratory conditions. HPIV3-related pathologies are often related to the overactive immune response of the host and it shares pathogenic pathways with RSV often compounding the severity of respiratory illnesses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Paramyxovirus Type 3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature methods 15:909-912 PubMed30377371

2018

A high-throughput pipeline for validation of antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Krzysztof Sikorski,Adi Mehta,Marit Inngjerdingen,Flourina Thakor,Simon Kling,Tomas Kalina,Tuula A Nyman,Maria Ekman Stensland,Wei Zhou,Gustavo A de Souza,Lars Holden,Jan Stuchly,Markus Templin,Fridtjof Lund-Johansen
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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