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AB118554

Anti-PARL antibody

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(3 Publications)

Rabbit Polyclonal PARL antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PARL.

View Alternative Names

PSARL, PRO2207, PARL, Mitochondrial intramembrane cleaving protease PARL

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PARL antibody (AB118554)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PARL antibody (AB118554)

ab118554 at 5μg/ml staining PARL in Formalin-Fixed, Paraffin-Embedded Human pancreas tissue by immunohistochemistry.

Western blot - Anti-PARL antibody (AB118554)
  • WB

Unknown

Western blot - Anti-PARL antibody (AB118554)

Lane 1:

Western blot - Anti-PARL antibody (ab118554) at 1 µg/mL

Lane 2:

Western blot - Anti-PARL antibody (ab118554) at 2 µg/mL

All lanes:

3T3 cell lysate

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human PARL. The exact immunogen used to generate this antibody is proprietary information.

Q9H300

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed : 22354088). Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential (PubMed : 22915595). Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss (PubMed : 22915595). Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide (PubMed : 28288130, PubMed : 32573439). Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity (PubMed : 28288130). Also required for cleavage of STARD7 and TTC19 (PubMed : 28288130). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (PubMed : 14732705, PubMed : 17116872).
See full target information PARL
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:700 PubMed41052999

2025

PARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Shiyi Yin,Yibo Zhai,Run Song,Jiannan Wu,Yongjiang Zhang,Miao Yu,Hongxia Ma,Mengmeng Shen,Xiaoyi Lai,Weina Jin,Yunqi Xu,Junqiang Yan

Nature communications 16:5465 PubMed40593619

2025

Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Nuo Sun,Hayley Barta,Samhita Chaudhuri,Kangxuan Chen,Jiacheng Jin,Hongke Luo,Mingchong Yang,Judith Krigman,Ruohan Zhang,Shridhar Sanghvi,Shiori Sekine,Hannah Sanders,Dominic Kolonay,Mudra Patel,Kedryn Baskin,Harpreet Singh,Pengyi Zhang,Gang Xin,Toren Finkel

British journal of pharmacology 176:787-800 PubMed30592786

2019

Epigenetic events involved in organic cation transporter 1-dependent impaired response of hepatocellular carcinoma to sorafenib.

Applications

Unspecified application

Species

Unspecified reactive species

Ruba Al-Abdulla,Elisa Lozano,Rocio I R Macias,Maria J Monte,Oscar Briz,Colm J O'Rourke,Maria A Serrano,Jesus M Banales,Matias A Avila,Maria L Martinez-Chantar,Andreas Geier,Jesper B Andersen,Jose J G Marin
View all publications
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