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AB121028

Anti-Parotid secretory protein antibody

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(2 Publications)

Goat Polyclonal BPI fold-containing family A member 2 precursor antibody. Suitable for ICC/IF and reacts with Mouse samples. Cited in 2 publications.
1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Parotid secretory protein antibody (AB121028)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Parotid secretory protein antibody (AB121028)

Immunocytochemistry/immunofluorescence analysis of mouse submanidbular gland cells labelling parotid secretory protein with ab121028 at 4 μg/mL (blue). Cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100. Cells were counterstained with Ecad at 1/200 dilution (red). Nuclear DNA was labelled with DAPI (green).

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

ICC/IF

applications

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "4 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99.48% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Parotid secretory protein often called PSP or BPIFA2 acts mechanically by serving as a salivary protein with antimicrobial properties. PSP weights approximately 25 kDa. This protein is expressed abundantly in the parotid gland while also present in other exocrine glands like submandibular and sublingual glands. PSP may interact with other proteins to perform its function effectively as it binds to pathogens and hinders their growth.
Biological function summary

The protein influences immune defense in salivary secretions. PSP is part of salivary innate immune responses and works alongside other salivary proteins for maintaining oral health. This protein contributes to the barrier function against bacteria and viruses inside the mouth. PSP is capable of agglutination of microbes making their removal by saliva more efficient.

Pathways

PSP is extensively involved in the immune defense pathways of the oral cavity and initial gastrointestinal tract. In these pathways PSP functions within networks including proteins such as mucins and histatins which collectively contribute to oral homeostasis and microbial balance. PSP’s ability to bind bacteria supports its role in these pathways by enhancing the prevention of infection and inflammation.

PSP's dysfunction is associated with Sjögren's syndrome and dental caries. This protein shows decreased expression in Sjögren's syndrome an autoimmune disorder affecting exocrine glands. Moreover decreased PSP levels are linked with a higher risk of dental caries due to reduced microbial defense in the oral cavity. PSP’s interaction with other proteins like mucins highlights its importance in maintaining a healthy oral environment and protecting against such conditions.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:106660 PubMed37168562

2023

Evaluating the transcriptional landscape and cell-cell communication networks in chronically irradiated parotid glands.

Applications

Unspecified application

Species

Unspecified reactive species

Brenna A Rheinheimer,Mary C Pasquale,Kirsten H Limesand,Matthew P Hoffman,Alejandro M Chibly

Frontiers in physiology 13:884166 PubMed35574458

2022

Muc5b Contributes to Mucus Abnormality in Rat Models of Cystic Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Johnathan D Keith,Alexander G Henderson,Courtney M Fernandez-Petty,Joy M Davis,Ashley M Oden,Susan E Birket
View all publications

Product promise

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