Anti-PARP16 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The PARP16 protein also known as ARTD15 is a member of the poly (ADP-ribose) polymerase (PARP) family. It functions mechanically by transferring ADP-ribose units to target proteins a process known as ADP-ribosylation. The mass of PARP16 is approximately 37 kDa. It is widely expressed in various tissues with high levels found in pancreatic and liver tissues. PARP16 operates as part of cellular processes that involve DNA repair and maintenance of genomic stability.

Biological function summary

PARP16 plays a role in regulating the unfolded protein response (UPR) an important cellular mechanism to manage protein folding stress in the endoplasmic reticulum (ER). PARP16 associates with the ER and acts as a signaling hub during stress conditions. It modulates the activity of specific ER kinases such as PERK and IRE1 by facilitating their activation through ADP-ribosylation. This action places PARP16 as part of a complex regulatory network that maintains proper cellular function under stressful conditions.

Pathways

The ADP-ribosylation activity of PARP16 influences key pathways like the unfolded protein response and ER stress response pathways. It interacts with proteins like PERK and IRE1 to propagate stress signals necessary for managing ER stress. By linking up with these pathways PARP16 ensures the balance between protein synthesis and degradation helping cells adapt to challenges that affect protein folding. This protein has parallels with other PARP family members in how it affects cellular pathways sharing functional aspects in their roles.

Associated diseases and disorders

Aberrant activity of PARP16 links with conditions like cancer and metabolic disorders. In cancer misregulation of protein folding and stress response pathways where PARP16 plays a role can support tumor growth and survival. Studies indicate connections between PARP16 and proteins like IRE1 in driving survival pathways important for tumor cells. In metabolic disorders such as diabetes ER stress and unfolded protein response dysregulation partially mediated by PARP16 contribute to disease progression. Understanding these links highlights the importance of PARP16 as a potential drug target for related diseases.