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AB200390

Anti-PARP7 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal PARP7 antibody. N-terminal. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TIPARP.

View Alternative Names

PARP7, TIPARP, Protein mono-ADP-ribosyltransferase TIPARP, ADP-ribosyltransferase diphtheria toxin-like 14, Poly [ADP-ribose] polymerase 7, TCDD-inducible poly [ADP-ribose] polymerase, ARTD14, PARP-7

1 Images
Western blot - Anti-PARP7 antibody - N-terminal (AB200390)
  • WB

Supplier Data

Western blot - Anti-PARP7 antibody - N-terminal (AB200390)

Gel : 6%SDS-PAGE

All lanes:

Western blot - Anti-PARP7 antibody - N-terminal (ab200390) at 1/200 dilution

All lanes:

Mouse spleen tissue lysate at 40 µg

Predicted band size: 76 kDa

true

Exposure time: 5min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TIPARP. The exact immunogen used to generate this antibody is proprietary information.

Q7Z3E1

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PARP7 also known as Poly (ADP-ribose) polymerase 7 is an enzyme that serves a significant role in cellular processes. PARP7 belongs to the PARP family with a molecular mass of around 77 kDa. Found in the nucleus PARP7 performs its function largely within cells of the immune system. Structural analysis reveals that PARP7 has a DNA-binding domain as well as a catalytic domain necessary for its enzymatic activity which involves adding ADP-ribose units to proteins.
Biological function summary

PARP7 influences gene expression and the cellular response to stress. It participates in regulating transcription by modifying other proteins through ADP-ribosylation impacting gene expression directly. PARP7 is not a part of a larger protein complex but collaborates with components in the immune system pathway to facilitate the innate immune response. Its function helps to maintain the equilibrium between different cellular processes and stress handling ensuring the proper cellular function.

Pathways

PARP7 integrates into the interferon and oxidative stress response pathways. The PARP7 enzyme interacts with proteins like interferon regulatory factors and plays a role in modulating antiviral responses ensuring efficient communication within cells when they encounter stress or infection. Additionally through its activity PARP7 influences pathways involving members of the same PARP protein family highlighting its interconnected role in cellular signaling processes.

PARP7 has links to certain cancers and autoimmune diseases. Aberrant PARP7 activity has been observed in some cancer types with research indicating that abnormal expression or mutations may contribute to tumor progression. In autoimmune diseases PARP7 might affect the immune response potentially altering outcomes in conditions such as lupus. In these contexts PARP7 might interact with specific proteins like STAT1 or other regulatory proteins which have key roles in both disease development and progression.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed : 23275542, PubMed : 25043379, PubMed : 30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed : 23275542, PubMed : 30373764).
See full target information TIPARP

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in genetics 11:582796 PubMed33193710

2020

Gene and Protein Expression in Subjects With a Nystagmus-Associated AHR Mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Borovok,Celeste Weiss,Rajech Sharkia,Michal Reichenstein,Bernd Wissinger,Abdussalam Azem,Muhammad Mahajnah
View all publications

Product promise

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