Anti-PARP8 antibody - C-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PARP8 also called Poly (ADP-ribose) polymerase family member 8 is a protein with a molecular mass of about 75 kDa. It belongs to the PARP family involved in catalyzing the transfer of ADP-ribose units from NAD+ to target proteins. PARP8 is found in various tissues including the brain liver and lungs. It plays a role in protein interactions mediating cellular processes and signaling.

Biological function summary

Four distinct processes involve PARP8's actions in regulating transcription processes genome stability and DNA damage response. PARP8 may interact in complexes that further influence cellular responses to stress. It manages chromatin structure through poly-ADP-ribosylation affecting gene expression and cellular resilience against genotoxic stressors.

Pathways

A couple of critical pathways engage PARP8's role in managing cellular equilibrium. The DNA damage response (DDR) pathway includes PARP8 collaborating with proteins like ATM and ATR which are involved in sensing DNA damage and promoting repair mechanisms. Additionally the transcriptional regulation pathway involves PARP8 affecting gene expression by modulating chromatin structure and interacting with transcription factors.

Associated diseases and disorders

Several pathological conditions implicate PARP8 through its regulatory functions in cellular stress responses. Cancer is notable where abnormal PARP8 activity could disrupt genome stability and facilitate tumor progression. Inflammatory diseases also show connections with PARP8 activity involving its interaction with other PARP family members like PARP1 modulating inflammatory responses. Alterations in these pathways may contribute to understanding disease mechanisms and therapeutic interventions.