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AB256811

Anti-Parvalbumin antibody

5

(1 Review)

|

(3 Publications)

Rabbit Polyclonal Parvalbumin antibody. Suitable for WB, IHC-Fr and reacts with Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Pvalb.

View Alternative Names

Pva, Pvalb, Parvalbumin alpha, Alpha-parvalbumin, Alpha-PV

3 Images
Immunohistochemistry (Frozen sections) - Anti-Parvalbumin antibody (AB256811)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-Parvalbumin antibody (AB256811)

Frozen-sectioned mouse hippocampus stained for Parvalbumin using ab256811 at 1/250 dilution (green). Counterstained with Fluoroshield with DAPI (blue).

Immunohistochemistry (Frozen sections) - Anti-Parvalbumin antibody (AB256811)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-Parvalbumin antibody (AB256811)

Frozen-sectioned mouse cerebellum stained for Parvalbumin using ab256811 at 1/250 dilution (green). Counterstained with Fluoroshield with DAPI (blue). NF-H stained red.

Western blot - Anti-Parvalbumin antibody (AB256811)
  • WB

Supplier Data

Western blot - Anti-Parvalbumin antibody (AB256811)

15% SDS-PAGE

All lanes:

Western blot - Anti-Parvalbumin antibody (ab256811) at 1/10000 dilution

All lanes:

Rat cerebellum lysate at 50 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 12 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB, IHC-Fr

applications

Immunogen

Recombinant Fragment Protein within Mouse Pvalb. The exact immunogen used to generate this antibody is proprietary information.

P32848

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/20000", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/100 - 1/1000", "IHCFr-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/20000", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Parvalbumin sometimes referred to as PV is a calcium-binding protein approximately 12 kDa in size. It is recognized for its roles in muscle and neuronal tissues. Within the nervous system parvalbumin is prominently expressed in fast-spiking GABAergic interneurons while in muscle tissues it is present in fast-twitch muscle fibers. Other popular descriptors include anti PV and parvalbumins. These proteins play important roles in the regulation of cellular calcium levels.
Biological function summary

Parvalbumin helps modulate calcium ion concentration which is key in muscle relaxation and neurotransmission. It acts by buffering calcium ions and is not part of a larger protein complex. By impacting calcium transients parvalbumin affects processes like synaptic plasticity and the rapid contractions of muscle fibers. This is especially significant in the brain where rapid neuronal firing is needed and in muscles where quick recovery is essential.

Pathways

Parvalbumin is intimately linked with calcium signaling pathways as well as the regulation of muscle contraction. It ensures proper calcium ion homeostasis thereby aiding muscle relaxation after contraction. In the nervous system calbindin proteins parallel some of parvalbumin's functions participating in calcium ion buffering and modulation of neuron excitability. The balanced action of these proteins helps maintain cellular functions in both neurons and muscles.

Insufficient parvalbumin expression may link to epilepsy and schizophrenia. Deficits in this protein could interfere with normal neurotransmission and muscle relaxation cycles. Parvalbumin deficiency influences neurotransmitter release affecting synaptic transmission which may exacerbate symptoms in these conditions. In disease mechanisms proteins such as calbindin may indirectly relate with parvalbumin showing similar patterns of dysregulation and compensating for its absence in calcium handling.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

In muscle, parvalbumin is thought to be involved in relaxation after contraction (By similarity). It binds two calcium ions (By similarity).
See full target information Pvalb
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1592737 PubMed40799648

2025

RORα-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Song,Haiyan Shen,Fei Hong,Weiyan Zhang,Hongyi Lu

Science advances 8:eabn5899 PubMed36044580

2022

Crossing nerve transfer drives sensory input-dependent plasticity for motor recovery after brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengrun Gao,Zhen Pang,Gaowei Lei,Yiming Chen,Zeyu Cai,Shuai Zhu,Weishan Lin,Zilong Qiu,Yizheng Wang,Yundong Shen,Wendong Xu

Cerebellum (London, England) 19:358-369 PubMed32002801

2020

The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals.

Applications

Unspecified application

Species

Unspecified reactive species

Mégane Homa,Anne Loyens,Sabiha Eddarkaoui,Emilie Faivre,Vincent Deramecourt,Claude-Alain Maurage,Luc Buée,Vincent Huin,Bernard Sablonnière
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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