Anti-Pasteurella multocida toxin antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Pasteurella multocida toxin commonly referred to as PMT is a single-chain polypeptide with a molecular weight of approximately 146 kilodaltons. PMT is a potent virulence factor expressed by the bacterium Pasteurella multocida predominantly in cells infected by this pathogen. This toxin modulates host cellular functions through its manipulative activities on G-proteins leading to an alteration of host signaling pathways. PMT directly targets the alpha subunits of heterotrimeric G-proteins causing their persistent activation.

Biological function summary

The Pasteurella multocida toxin plays a significant role in modulating cellular processes by acting on key signalling pathways. It induces cellular morphological changes proliferation and inhibits apoptosis by affecting various enzymes and signaling proteins notably the Rho and Ras GTPases. PMT is not part of a larger complex but functions as a solitary agent exerting widespread effects in the host cell. It also disrupts the actin cytoskeleton leading to cellular architecture alterations.

Pathways

The Pasteurella multocida toxin influences several critical signaling cascades including the RhoA and MAPK pathways. These pathways are integral in cell cycle regulation cytoskeletal reorganization and gene expression. Through these pathways PMT indirectly interacts with proteins such as ROCK and MEK which contribute to the downstream signaling events. The persistent activation caused by PMT may lead to uncontrolled growth signaling and transformation events within the affected cells.

Associated diseases and disorders

The Pasteurella multocida toxin is associated with pasteurellosis in animals including respiratory and systemic infections. This toxin plays a direct role in disease pathogenesis by contributing to the symptoms and severity of the infection. PMT-related activation of signaling pathways has indirect links to other disorders such as an increased understanding of its effects on cellular proliferation could provide insights into cancer mechanisms. Through disease models researchers also examine connections to other bacterial toxins including the pertussis toxin due to similar mechanisms of G-protein dysregulation.