Rabbit Polyclonal PAX6 antibody. Suitable for IHC - Wmt and reacts with Zebrafish samples. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish pax6a aa 1-300.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Zebrafish pax6a aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P26630
Reactivity data
Select an application| IHC - Wmt | |
|---|---|
| Zebrafish | Tested |
IHC - Wmt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info 1/100 - 1/500 | Notes - |
Associated Products
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Target data
Function
Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development.
Alternative names
pax[zf-a], paxzf-a, si:dkeyp-46c10.1, pax6a, Paired box protein Pax-6, Pax[Zf-a]
Recommended products
Rabbit Polyclonal PAX6 antibody. Suitable for IHC - Wmt and reacts with Zebrafish samples. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish pax6a aa 1-300.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Zebrafish pax6a aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P26630
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
(Please refer to the vial label for the specific concentration)
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The PAX6 protein also known as paired box 6 is a transcription factor involved in the development of eyes and neural tissues. It consists of a paired domain and a homeodomain collectively giving a molecular weight of approximately 48 kDa. This protein is highly expressed in developing ocular and central nervous tissues where it controls the expression of genes necessary for proper development. PAX6 is a widely studied marker in developmental biology due to its critical role in cellular differentiation and patterning processes.
- Biological function summary
PAX6 acts as an important regulator in eye and neural development functioning alone and as part of larger complexes with other transcription factors. This role ensures the correct formation of ocular structures including the lens retina and cornea and neural elements by activating downstream targets important for cell fate decisions. The PAX6 protein intricately influences the genetic circuits that guide stem cell differentiation highlighting its importance in embryogenesis and organogenesis.
- Pathways
PAX6 is pivotal in the Wnt signaling pathway and retinoic acid signaling. Its interaction within the Wnt pathway orchestrates vital developmental processes including those of eye morphogenesis and brain patterning. The protein collaborates with other transcriptional regulators such as SOX2 and EYA1 within these pathways facilitating the complex network of signals necessary for organ development and cellular identity specification.
- Associated diseases and disorders
PAX6 mutations have strong associations with aniridia and congenital eye malformations. Mutations in PAX6 disrupt the transcriptional regulation required for eye development often resulting in severe vision defects and structural anomalies. The intracacy of its involvement extends to disorders like Wilms' tumor wherein its altered expression or function in conjunction with proteins such as WT1 may contribute to oncogenesis. Scientists frequently use PAX6 staining to investigate these conditions and better understand their molecular underpinnings.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
IHC - Wholemount - Anti-PAX6 antibody (ab209836)
Immunohistochemical analysis of paraformaldehyde-fixed zebrafish embryos labeling PAX6 with ab209836 at 1/200.
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