AB199010

Anti-PAX7 antibody [PAX7497]

Name: Anti-PAX7 antibody [PAX7497] (ab199010) | Abcam
Brand: Abcam Limited
SKU: AB199010
Price: 605 USD
Availability: InStock
Rating: 4 (2 reviews)

(2 Reviews)

(22 Publications)

Mouse Monoclonal PAX7 antibody. Suitable for WB and reacts with Human samples. Cited in 22 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PAX7.

View Alternative Names

HUP1, PAX7, Paired box protein Pax-7, HuP1

1 Images

Supplier Data

Western blot - Anti-PAX7 antibody [PAX7497] (AB199010)

All lanes:

Western blot - Anti-PAX7 antibody [PAX7497] (ab199010) at 1 µg/mL

All lanes:

HeLa cell lysate

Predicted band size: 56 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

PAX7497

Isotype

IgG1

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human PAX7.

P23759

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PAX7 or paired box 7 is a member of the paired box (PAX) family of transcription factors. Alternative names for PAX7 include PAX7 protein and PAX7 FACS. This protein has a molecular weight of approximately 57 kDa. PAX7 is mainly expressed in muscle precursor cells where it plays an important role in regulating muscle development. Researchers commonly detect it through PAX7 staining techniques in laboratory settings.

Biological function summary

PAX7 functions are important for muscle cell proliferation and differentiation. It works within a transcriptional complex where it partners with other proteins to promote satellite cell maintenance. Satellite cells are essential for muscle regeneration and PAX7 regulates their self-renewal and differentiation. The protein also modulates various genetic targets that affect the muscle cellular environment ensuring proper muscle function and repair.

Pathways

PAX7 is involved in the myogenic regulatory pathways that guide muscle development and regeneration. It interacts with important proteins like MyoD and Myf5 to influence these processes. These pathways facilitate the conversion of satellite cells into mature muscle fibers important during muscle growth and healing. PAX7’s function in these pathways ensures satellite cells remain active and capable of muscle repair throughout an organism's life.

PAX7’s dysfunction can lead to muscle-related conditions such as rhabdomyosarcoma and certain muscle dystrophies. In rhabdomyosarcoma improper regulation of PAX7 leads to unchecked cellular proliferation contributing to tumor growth. This disorder links PAX7 to other proteins in the tumorigenic pathway such as PAX3 which similarly influences muscle cell behavior in pathological states. Identifying PAX7 alterations can guide diagnosis and therapeutic strategies in muscle-associated disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.

See full target information PAX7

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Publications (22)

Recent publications for all applications. Explore the full list and refine your search

The European journal of neuroscience 62:e70235 PubMed40960371

2025

Electrical Stimulation-Induced Muscle Damage Alters Hippocampal BDNF Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Julien Wirtz,Rémi Chaney,Marina Cefis,Alexandre Méloux,Yuan Wang,Stéphanie Lemaire,Aurore Quirié,Julien Delezie,Gilles Gouspillou,Anne Prigent-Tessier,Philippe Garnier

Nutrients 17: PubMed40005024

2025

Sodium Butyrate Alleviates Heat Stress-Induced Oxidative Stress and Skeletal Muscle Homeostasis Disruption by Promoting Autophagy in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jiayin Lu,Chaoyue Li,Tong Zhao,Fengyang Li,Zhichao Yao,Yajie Dong,Zeen Gong,Yi Yan,Xiaomao Luo,Haidong Wang

Journal of cachexia, sarcopenia and muscle 16:e13708 PubMed39887939

2025

Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Ziyi Chen,Jiankun Xu,Peijie Hu,Wanting Du,Junjiang Chen,Xiaotian Zhang,Wei Zhou,Jiayang Gao,Yuantao Zhang,Bingyang Dai,Guangshuai Nie,Jun Hu,Liangbin Zhou,Shunxiang Xu,Hisao Chang Chan,Wing-Hoi Cheung,Ye Chun Ruan,Ling Qin

Cell death & disease 15:200 PubMed38459002

2024

p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence.

Applications

Unspecified application

Species

Unspecified reactive species

Yaiza Potes,Juan C Bermejo-Millo,Catarina Mendes,José P Castelão-Baptista,Andrea Díaz-Luis,Zulema Pérez-Martínez,Juan J Solano,Vilma A Sardão,Paulo J Oliveira,Beatriz Caballero,Ana Coto-Montes,Ignacio Vega-Naredo

Aging 16:4609-4630 PubMed38428405

2024

Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaorui Cao,Linli Xue,Xiuju Yu,Yi Yan,Jiayin Lu,Xiaomao Luo,Haidong Wang,Juan Wang

Cell death & disease 14:321 PubMed37173309

2023

Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Wang,Bichun Zhao,Jinglei Zhai,Ailin Wang,Ning Cao,Tuling Liao,Ruyu Su,Lijuan He,Yanhua Li,Xuetao Pei,Yali Jia,Wen Yue

BMC biology 21:19 PubMed36726129

2023

Integrative single-cell RNA-seq and ATAC-seq analysis of myogenic differentiation in pig.

Applications

Unspecified application

Species

Unspecified reactive species

Shufang Cai,Bin Hu,Xiaoyu Wang,Tongni Liu,Zhuhu Lin,Xian Tong,Rong Xu,Meilin Chen,Tianqi Duo,Qi Zhu,Ziyun Liang,Enru Li,Yaosheng Chen,Jianhao Li,Xiaohong Liu,Delin Mo

FEBS open bio 12:2213-2226 PubMed36325691

2022

Myoblast-derived exosomes promote the repair and regeneration of injured skeletal muscle in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shusen Ji,Pei Ma,Xiaorui Cao,Juan Wang,Xiuju Yu,Xiaomao Luo,Jiayin Lu,Wei Hou,Zhijuan Zhang,Yi Yan,Yanjun Dong,Haidong Wang

Scientific reports 12:311 PubMed35013359

2022

Endothelial cells are an important source of BDNF in rat skeletal muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Marina Cefis,Remi Chaney,Aurore Quirié,Clélia Santini,Christine Marie,Philippe Garnier,Anne Prigent-Tessier

Journal of cachexia, sarcopenia and muscle 12:1741-1756 PubMed34435457

2021

Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα mesenchymal progenitors.

Applications

Unspecified application

Species

Unspecified reactive species

Guo-Kai Shang,Lu Han,Zhi-Hao Wang,Ming Song,Di Wang,Yan-Min Tan,Yi-Hui Li,Yu-Lin Li,Wei Zhang,Ming Zhong

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PAX7 antibody [PAX7497]

Western blot - Anti-PAX7 antibody [PAX7497] (AB199010)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (22)

Product promise