Rabbit Monoclonal PAX8 antibody. Suitable for IHC-P, IHC-Fr and reacts with Mouse, Rat, Human samples. Immunogen corresponding to Synthetic Peptide within Human PAX8.
Preservative: 0.1% Sodium azide
Constituents: 99% Tissue culture supernatant, 0.2% BSA
| IHC-P | IHC-Fr | |
|---|---|---|
| Human | Expected | Expected |
| Mouse | Expected | Expected |
| Rat | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info Use at an assay dependent concentration. | Notes - |
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Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Paired box protein Pax-8, PAX8
Rabbit Monoclonal PAX8 antibody. Suitable for IHC-P, IHC-Fr and reacts with Mouse, Rat, Human samples. Immunogen corresponding to Synthetic Peptide within Human PAX8.
Preservative: 0.1% Sodium azide
Constituents: 99% Tissue culture supernatant, 0.2% BSA
PAX8 also known as 3a8 is a transcription factor with a molecular mass of approximately 48 kDa. It belongs to the paired box (PAX) family of proteins which are characterized by a specific DNA-binding domain. PAX8 plays an important role in organ development and cellular differentiation. This protein is mainly expressed in the thyroid kidneys and Müllerian-derived tissues. Researchers often detect PAX8 using immunohistochemistry (PAX8 IHC) techniques due to its tissue-specific expression patterns.
The PAX8 protein regulates the expression of genes related to organogenesis and cell fate determination. It forms part of transcriptional regulatory complexes partnering with other proteins to modulate gene activity. PAX8 supports embryonic development especially in the thyroid and urogenital tract. Its presence ensures the proper function and formation of these organs highlighting its significance in developmental biology.
PAX8 interacts with several key biological processes. It notably participates in the thyroid hormone synthesis pathway where it regulates the expression of thyroglobulin and thyroperoxidase. PAX8 also affects the renal system through its interaction with WT1 a protein involved in kidney development. These pathways illustrate PAX8's role in maintaining endocrine and renal functions by influencing important protein interactions.
PAX8 mutations and dysregulation connect to conditions like congenital hypothyroidism and renal agenesis. In congenital hypothyroidism defects in PAX8 lead to impaired thyroid development affecting hormone production. Moreover its interaction with BCL2 an important apoptosis regulator relates to certain cancers such as ovarian carcinoma. The misregulation of PAX8 increases the risk and progression of these disorders by disrupting normal physiological processes.
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