AB109173

Anti-Pbx3 antibody [EPR2833(2)]

Name: Anti-Pbx3 antibody [EPR2833(2)] (ab109173) | Abcam
Brand: Abcam Limited
SKU: AB109173
Price: 365 USD
Availability: InStock
Rating: 4 (1 reviews)

RabMAb
Recombinant
What is this?

(1 Review)

(14 Publications)

Rabbit Recombinant Monoclonal PBX3 antibody. Suitable for WB and reacts with Human samples. Cited in 14 publications.

View Alternative Names

Pre-B-cell leukemia transcription factor 3, Homeobox protein PBX3, PBX3

1 Images

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Western blot - Anti-Pbx3 antibody [EPR2833(2)] (AB109173)

All lanes:

Western blot - Anti-Pbx3 antibody [EPR2833(2)] (ab109173) at 1/1000 dilution

Lane 1:

Human fetal brain lysate at 10 µg

Lane 2:

A431 cell lysate at 10 µg

Lane 3:

HeLa cell lysate at 10 µg

Predicted band size: 47 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR2833(2)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pbx3 also known as pre-B-cell leukemia transcription factor 3 is a transcription factor that belongs to the TALE/PBX homeobox family. It has an approximate mass of 47 kDa and usually expresses in tissues such as the brain and the pancreas. Mechanically Pbx3 regulates gene expression by binding to specific DNA sequences and forming complexes with other transcription factors. Its function is important for the transcriptional regulation process during developmental stages.

Biological function summary

Pbx3 plays a significant role in the development of several tissues including the central nervous system. It frequently associates with other proteins like Meis1 and HoxB1 to form transcriptional complexes that regulate essential genes involved in cell differentiation and organogenesis. These complexes mediate the control of target gene activity ensuring proper embryonic development and cellular differentiation.

Pathways

Pbx3 participates in critical regulatory networks such as the retinoic acid signaling pathway and the hematopoietic stem cell differentiation pathway. In these pathways Pbx3 acts in conjunction with proteins like Hox genes and Meis proteins influencing the transcriptional regulation important for tissue specification and stem cell renewal. This functional interaction allows Pbx3 to contribute significantly to developmental processes and cellular programming.

Pbx3 has significant implications in conditions like acute lymphoblastic leukemia and diabetes mellitus. In acute lymphoblastic leukemia Pbx3 interacts with oncogenic fusion proteins such as E2A-Pbx1 contributing to the malignancy's development by altering normal transcriptional regulation. In diabetes its expression levels affect pancreatic development and insulin regulation linking it to metabolic disturbances associated with the disorder.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.

See full target information PBX3

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Molecular cancer 22:196 PubMed38049829

2023

Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Nuria Tubío-Santamaría,Ashok Kumar Jayavelu,Tina M Schnoeder,Theresa Eifert,Chen-Jen Hsu,Florian Perner,Qirui Zhang,Daniela V Wenge,Fynn M Hansen,Joanna M Kirkpatrick,Nidhi Jyotsana,Steven W Lane,Björn von Eyss,Aniruddha J Deshpande,Michael W M Kühn,Juerg Schwaller,Clemens Cammann,Ulrike Seifert,Frédéric Ebstein,Elke Krüger,Andreas Hochhaus,Michael Heuser,Alessandro Ori,Matthias Mann,Scott A Armstrong,Florian H Heidel

Journal of clinical laboratory analysis 36:e24733 PubMed36371782

2022

Knockdown of hsa_circ_0043691 restrains the progression of gastric cancer by decoying miR-1294 to target pre-leukemia transcription factor 3.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wu,Pan Gong,Zhiyong Jiang

Journal of oncology 2022:2081501 PubMed35646117

2022

CircNRIP1 Exerts Oncogenic Functions in Papillary Thyroid Carcinoma by Sponging miR-653-5p and Regulating PBX3 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Lijun Fu,Jia Huo,Habibullah Fitrat,Yujing Kong,Lingyu Zhang,Chaoyang Shang,Guoquan Li,Feihong Ji,Xinghao Fu,Xinguang Qiu

Journal of oncology 2022:2832920 PubMed35342419

2022

circNBPF10/miR-224 Axis Regulates PBX3 to Promote the Malignant Progression of Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xuguang Zhao,Xiao Song,Yanxia Zhao

Bioengineered 13:4153-4165 PubMed35142595

2022

Long non-coding RNA DSCAM-AS1 promotes pancreatic cancer progression via regulating the miR-136-5p/PBX3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Huang,Zihe Wang,Shengzhong Hou,Chao Yue,ZhenLu Li,Weiming Hu,Huimin Lu

Molecular therapy oncolytics 25:201-210 PubMed35592389

2022

PBX3-activated DLG1-AS1 can promote the proliferation, invasion, and migration of TNBC cells by sponging miR-16-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Huiming Zhang,Xianquan Shi,Zhicheng Ge,Zihan Wang,Yinguang Gao,Guoxuan Gao,Wei Xu,Xiang Qu

Cancer cell international 21:264 PubMed34001137

2021

Circular RNA circHECTD1 prevents Diosbulbin-B-sensitivity via miR-137/PBX3 axis in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yizhuo Lu,Long Li,Lianghui Li,Guoyang Wu,Guoyan Liu

Saudi journal of biological sciences 27:2157-2163 PubMed32714042

2020

MG132 inhibits the expression of PBX3 through miRNAs by targeting Argonaute2 in hepatoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Daiyong Mou,Xiaodan Yang,Sheng Li,Wei Zhao,Meng Li,Maoji Zhao,Nasser Hadal Alotaibi,Zhiqian Zhang,Min Tang,Khalid Saad Alharbi,Joob Bahman,Syed Nasir Abbas Bukhari,Cristina Dézlla

World journal of gastrointestinal oncology 11:842-856 PubMed31662823

2019

MicroRNA-320a suppresses tumor progression by targeting PBX3 in gastric cancer and is downregulated by DNA methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Yong-Shuang Li,Ying Zou,Dong-Qiu Dai

Journal of experimental & clinical cancer research 37:158 PubMed30016974

2018

PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Xiupeng Xu,Zhongyuan Bao,Yinlong Liu,Kuan Jiang,Tongle Zhi,Dong Wang,Liang Fan,Ning Liu,Jing Ji

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Pbx3 antibody [EPR2833(2)]

Western blot - Anti-Pbx3 antibody [EPR2833(2)] (AB109173)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (14)

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