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AB230408

Anti-PCDH10 antibody

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(1 Publication)

Rabbit Polyclonal PCDH10 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PCDH10 aa 500-750.

View Alternative Names

KIAA1400, PCDH10, Protocadherin-10

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH10 antibody (AB230408)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH10 antibody (AB230408)

Paraffin-embedded human brain tissue stained for PCDH10 using ab230408 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH10 antibody (AB230408)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH10 antibody (AB230408)

Paraffin-embedded human glioma tissue stained for PCDH10 using ab230408 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PCDH10 aa 500-750. The exact immunogen used to generate this antibody is proprietary information.

Q9P2E7

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Complementary Products

Proteins & Peptides

AB153775

Recombinant Human PCDH10 protein

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Primary Antibodies

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Primary Antibodies

AB182858

Anti-Bcl-2 antibody [EPR17509]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl-2 antibody [EPR17509] (AB182858)

  • 5
  • 13
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDH10 known also as Protocadherin-10 is a member of the cadherin superfamily responsible for calcium-dependent cell-cell adhesion. This protein typically has a mass of around 130 kDa and is characterized by its large extracellular domain composed of cadherin repeats. PCDH10 is mainly expressed in the brain particularly in regions involved in learning and memory. Its expression patterns suggest that it plays a significant role in neural development and synaptic connectivity.
Biological function summary

Protocadherin-10 is involved in the establishment and maintenance of specific cell-cell connections. It is not part of any known complex but interacts with cytoskeletal elements to facilitate cellular architecture and signaling. PCDH10 thereby contributes to proper functioning of neuronal circuits. The correct expression of PCDH10 influences the dynamics of neuronal networks and neuronal communication.

Pathways

PCDH10 participates in signaling pathways linked to neuronal development and synaptic plasticity such as the Wnt pathway. It is indirectly related to several proteins within the Wnt pathway that are important in guiding neuronal growth and differentiation. PCDH10 may work alongside other protocadherins interacting with signaling cascades that coordinate synapse formation and stabilization.

Several studies have implicated abnormalities in PCDH10 expression with neuropsychiatric disorders including autism spectrum disorder (ASD) and schizophrenia. These disorders often show disrupted neural connectivity likely linked to altered PCDH10 function. In ASD for instance abnormalities in PCDH10 potentially interact with other proteins such as neuroligins that play roles in synaptic formation and function hinting at complex interplay in these pathologies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Potential calcium-dependent cell-adhesion protein.. (Microbial infection) Acts as a receptor for Western equine encephalitis virus.
See full target information PCDH10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of oncology 54:1233-1244 PubMed30968153

2019

Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Shun Wu,Zhu-Feng Li,Hao-Fan Wang,Xiang-Hua Yu,Xin Pang,Jing-Biao Wu,Sha-Sha Wang,Mei Zhang,Xiao Yang,Ming-Xin Cao,Ya-Jie Tang,Xin-Hua Liang,Min Zheng,Ya-Ling Tang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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