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AB230346

Anti-PCDH15 antibody

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(1 Publication)

Rabbit Polyclonal PCDH15 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PCDH15 aa 150-400.

View Alternative Names

USH1F, PCDH15, Protocadherin-15

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH15 antibody (AB230346)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH15 antibody (AB230346)

Paraffin-embedded human testis tissue stained for PCDH15 with ab230346 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PCDH15 aa 150-400. The exact immunogen used to generate this antibody is proprietary information.

Q96QU1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDH15 also known as Protocadherin-15 is a protein encoded by the PCDH15 gene. Mechanically this protein functions as an adhesion molecule in the body playing an important role in cell-cell interactions. PCDH15 has a molecular mass of approximately 223 kDa. It has a widespread expression but is particularly found in sensory cells in the inner ear and in the retina of the eye highlighting its importance in sensory functions.
Biological function summary

PCDH15 participates in the formation of tip-link structures within the inner ear. This protein is a component of the mechanotransduction complex which translates mechanical stimuli into electrical signals. PCDH15 works alongside other proteins like Cadherin 23 another protocadherin to maintain the integrity of hair cells. Its role is essential for proper auditory and visual signal processing contributing to the sense of hearing and vision.

Pathways

PCDH15 interacts with the mechanotransduction pathway in sensory cells. This pathway plays a role in converting mechanical stimuli such as sound waves in the cochlea into nerve impulses. Cadherin 23 is closely related in this pathway and together these proteins maintain the hair cell structure necessary for mechanotransduction. The interplay between these proteins ensures the transduction of sensory information impacting cellular responses in sensory organs.

PCDH15 mutations associate with Usher syndrome type 1F and non-syndromic hearing loss. Usher syndrome is a genetic condition involving hearing loss and vision impairment. PCDH15 mutations disrupt the mechanotransduction complex affecting sensory perception. Cadherin 23 also connects to these disorders as mutations in this protein can similarly lead to issues in hearing and vision. Understanding PCDH15 and its interactors is critical in addressing these sensory disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
See full target information PCDH15
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of oral & facial pain and headache 39:196-203 PubMed40129438

2025

Loss of SCRG1 in chondrocytes inhibits osteoarthritis by promoting autophagy activity in the temporomandibular joint through inhibition of neurokine receptors.

Applications

Unspecified application

Species

Unspecified reactive species

JiaJun Zhang,LePing Yuan,YanYan Zhang,HaoYang Jin,YeKe Zhao,XiaoKe Zeng,YanHui Zou,KeYu Wang,Xin Nie
View all publications
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Product promise

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