Rabbit Polyclonal PCDH18 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human PCDH18 aa 750-900.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PCDH18 aa 750-900. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HCL0
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Expected |
| Mouse | Expected | Tested |
| Cow | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 0.04000-0.40000 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow | Dilution info - | Notes - |
Target data
Function
Potential calcium-dependent cell-adhesion protein.
Alternative names
KIAA1562, PCDH18, Protocadherin-18
Recommended products
Rabbit Polyclonal PCDH18 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human PCDH18 aa 750-900.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PCDH18 aa 750-900. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HCL0
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein PCDH18 also known as Protocadherin 18 is part of the protocadherin family which consists of diverse cell-adhesion molecules. PCDH18 has a known mass of approximately 115 kDa. It plays a significant role in cell-cell communication and is mainly expressed in the brain particularly in the developing neural tissues. Its expression in neural tissues suggests it participates in the intricate processes involved in the development and maintenance of neuronal connections.
- Biological function summary
PCDH18 acts as a cell adhesion molecule contributing to the establishment and maintenance of specific cell-cell contacts. It does not appear to be part of a larger complex but interacts with other cell adhesion molecules to influence neuronal networking and synaptic integrity. This protein aids in the regulation of neural circuit assembly and plasticity which are essential for proper brain function and cognitive processes.
- Pathways
The role of PCDH18 in neural connections fits within key neuronal signaling pathways. One major pathway is the Wnt signaling pathway which influences cell movement and polarity in the developing nervous system. PCDH18 interacts with other proteins involved in this pathway such as beta-catenin to modulate signaling that affects neuronal patterning and synapse formation. Furthermore its interaction within cadherin-related pathways connects it with proteins like N-cadherin which collaborates in neural development and synapse configuration.
- Associated diseases and disorders
The function of PCDH18 links to two main neurological conditions: schizophrenia and autism spectrum disorders. Alterations in PCDH18 expression can disrupt synaptic functions leading to these cognitive and social interaction impairments. Additionally PCDH18 relates with other proteins involved in these disorders such as Neurexin and Neuroligin which are important in synapse maintenance and neural circuitry. Understanding these connections offers potential pathways for therapeutic targets in managing these neurological conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH18 antibody (ab224404)
Paraffin-embedded human placenta tissue stained for PCDH18 using ab224404 at 1/50 dilution in immunohistochemical analysis.
Western blot - Anti-PCDH18 antibody (ab224404)
All lanes: Western blot - Anti-PCDH18 antibody (ab224404) at 1/100 dilution
Lane 1: Mouse liver lysate
Lane 2: Rat liver lysate
Predicted band size: 126 kDa
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