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AB191198

Anti-PCDH19 antibody - C-terminal

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(3 Publications)

Rabbit Polyclonal PCDH19 antibody. C-terminal. Suitable for WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PCDH19 aa 1050 to C-terminus.

View Alternative Names

KIAA1313, PCDH19, Protocadherin-19

1 Images
Western blot - Anti-PCDH19 antibody - C-terminal (AB191198)
  • WB

Supplier Data

Western blot - Anti-PCDH19 antibody - C-terminal (AB191198)

All lanes:

Western blot - Anti-PCDH19 antibody - C-terminal (ab191198) at 1 mg/mL

Lane 1:

Whole cell lysate from HeLa cells in RIPA buffer at 50 µg

Lane 2:

Whole cell lysate from 293T cells in RIPA buffer at 50 µg

Lane 3:

Whole cell lysate from Jurkat cells in RIPA buffer at 50 µg

Lane 4:

Whole cell lysate from TCMK-1 cells in NETN buffer at 10 µg

Lane 5:

Whole cell lysate from NIH3T3 cells in NETN buffer at 10 µg

Predicted band size: 126 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PCDH19 aa 1050 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8TAB3

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDH19 also known as protocadherin-19 is a calcium-dependent cell adhesion protein. It has an approximate mass of 120 kDa. This protein is prominently expressed in the brain particularly in regions involved in cognitive processing and development such as the hippocampus and neocortex. PCDH19 plays an important role in the adhesive interactions that guide neurite outgrowth and axon targeting essential for proper neural network formation.
Biological function summary

Protocadherin-19 is part of the cadherin superfamily which includes other protocadherins that contribute to cell-cell adhesion and signaling. These proteins are known to form a complex with other cadherins at the cell membrane facilitating neuronal cell communication. PCDH19's ability to mediate cell adhesion and interaction is necessary for the organization of neural circuits fundamental for brain function.

Pathways

Research indicates that protocadherin-19 is important in signal transduction pathways related to synapse development and plasticity. Specifically it associates with the Wnt signaling pathway a critical pathway for neural development and synapse formation. Through this involvement PCDH19 interacts indirectly with other proteins like β-catenin which plays a role in the transcription regulation affecting cell fate decisions.

Researchers have linked PCDH19 mutations to epilepsy and intellectual disabilities particularly in females. This condition known as PCDH19-related epilepsy is often characterized by early-onset seizure and cognitive impairment. The protein also potentially interacts with γ-aminobutyric acid (GABA) receptor pathways which are central to epilepsy pathophysiology. Understanding PCDH19's role offers insights into therapeutic strategies for associated neurological disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Calcium-dependent cell-adhesion protein.
See full target information PCDH19
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 20:230 PubMed37805585

2023

Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Maria P Blasco Conesa,Frank W Blixt,Pedram Peesh,Romeesa Khan,Janelle Korf,Juneyoung Lee,Gayathri Jagadeesan,Alexander Andersohn,Tushar K Das,Chunfeng Tan,Claudia Di Gesu,Gabriela Delevati Colpo,Jose Félix Moruno-Manchón,Louise D McCullough,Robert Bryan,Bhanu P Ganesh

Neurobiology of disease 169:105738 PubMed35460869

2022

Mosaic and non-mosaic protocadherin 19 mutation leads to neuronal hyperexcitability in zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Barbara K Robens,Xinzhu Yang,Christopher M McGraw,Laura H Turner,Carsten Robens,Summer Thyme,Alexander Rotenberg,Annapurna Poduri

Molecular brain 14:113 PubMed34261484

2021

Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Wu,Yong Liu,Lishuo Liu,Qiang Meng,Changwang Du,Kuo Li,Shan Dong,Yong Zhang,Huanfa Li,Hua Zhang
View all publications
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