Anti-PCDH20 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PCDH20 also known as protocadherin-20 is a member of the protocadherin family that plays critical mechanical roles in cell-cell adhesion. It weighs approximately 116 kDa and is most frequently expressed in the nervous system especially in the brain. This protein contributes to the formation and maintenance of specific neural connections enabling proper neural communication and tissue architecture.

Biological function summary

Protocadherin-20 engages in mediating homophilic interactions essential for cell signaling and communication. It is part of a larger protocadherin complex that contributes to diverse cellular processes including cell recognition and positioning. The presence of PCDH20 influences the development and differentiation of neurons supporting intricate neural networks that dictate how signals propagate through the nervous system.

Pathways

The role of protocadherin-20 becomes evident in neural development and signaling pathways. It interacts with the Wnt signaling pathway which is important for aspects of neural patterning and synaptic maintenance. In conjunction with other protocadherin proteins PCDH20 coordinates with beta-catenin to regulate key activities within these pathways influencing neural patterning and connectivity.

Associated diseases and disorders

Deregulation of protocadherin-20 links to neurological disorders such as autism and intellectual disabilities. Abnormal expression of PCDH20 is associated with atypical synaptic connectivity which contributes to these conditions. Additionally its interaction with proteins like beta-catenin suggests a potential impact on neurodevelopmental pathways further tying protocadherin-20 to disorders affecting cognitive function.