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AB214189

Anti-PCDH7 antibody

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(2 Publications)

Rabbit Polyclonal PCDH7 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PCDH7 aa 450-550 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

BHPCDH, PCDH7, Protocadherin-7, Brain-heart protocadherin, BH-Pcdh

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH7 antibody (AB214189)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDH7 antibody (AB214189)

Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human glioma tissue labeling PCDH7 with ab214189 at 1/300 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PCDH7 aa 450-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O60245

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDH7 also known as Protocadherin 7 is a member of the protocadherin family falling under the broader cadherin superfamily. It has a mass of approximately 120 kDa. PCDH7 is a type I transmembrane protein known for its role in cellular adhesion. It is expressed in several tissues with higher expression in the nervous system and lungs. Its expression pattern suggests a role in specific tissue differentiation and development. As a protocadherin PCDH7 facilitates cell-cell interactions essential for maintaining tissue architecture.
Biological function summary

PCDH7 contributes to cell signaling and adhesion processes. It is not currently known to be a part of a large recognized complex but its interactions at the cell membrane influence cellular communication networks. In the nervous system PCDH7 supports neuronal connectivity and synaptic function aiding in the establishment of neural circuits. It also plays a part in epithelial cell layer formation aiding in maintaining proper cell alignment and barrier function. This supports PCDH7's classification as an important player in structural tissue integrity and intercellular communication.

Pathways

PCDH7 is involved in key signaling pathways that govern cellular adhesion and signaling dynamics. It plays a significant role in the Wnt signaling pathway important for cell proliferation differentiation and migration. PCDH7 interacts with proteins such as β-catenin which is a pivotal part of the Wnt pathway. Its regulation of cellular interactions helps maintain cellular structural organization ensuring normal development and response to cellular signals in specific tissues.

Researchers have linked PCDH7 to respiratory disorders and certain cancers. Studies demonstrate increased expression of PCDH7 in lung adenocarcinoma indicating its potential role in tumorigenesis. It associates with proteins like E-cadherin where misregulation can lead to altered cell adhesion and metastasis. PCDH7's involvement in this dysregulation hints at its potential as a biomarker for diagnosis or a target for therapeutic interventions in cancer treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information PCDH7
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature neuroscience 28:949-963 PubMed40259073

2025

Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia R Nano,Elisa Fazzari,Daria Azizad,Antoni Martija,Claudia V Nguyen,Sean Wang,Vanna Giang,Ryan L Kan,Juyoun Yoo,Brittney Wick,Maximilian Haeussler,Aparna Bhaduri

Journal of biochemical and molecular toxicology 38:e70001 PubMed39425457

2024

HIF1A/PCDH7 axis mediates fatty acid synthesis and metabolism to inhibit lung adenocarcinoma anoikis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Yang,Qingfeng Zhang,Liyang Wei,Kui Liu
View all publications
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