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Rabbit Polyclonal PCDH7 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PCDH7 aa 700-850.

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Images

Immunocytochemistry/ Immunofluorescence - Anti-PCDH7 antibody (AB220260), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human PCDH7 aa 700-850. The exact immunogen used to generate this antibody is proprietary information. Database link O60245

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ICC/IF
Human
Tested

Tested
Tested

Species
Human
Dilution info
0.25000-2.00000 µg/mL
Notes

-

Associated Products

Select an associated product type

4 products for Alternative Product

Target data

Alternative names

BHPCDH, PCDH7, Protocadherin-7, Brain-heart protocadherin, BH-Pcdh

Recommended products

Rabbit Polyclonal PCDH7 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PCDH7 aa 700-850.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human PCDH7 aa 700-850. The exact immunogen used to generate this antibody is proprietary information. Database link O60245
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

PCDH7 also known as Protocadherin 7 is a member of the protocadherin family falling under the broader cadherin superfamily. It has a mass of approximately 120 kDa. PCDH7 is a type I transmembrane protein known for its role in cellular adhesion. It is expressed in several tissues with higher expression in the nervous system and lungs. Its expression pattern suggests a role in specific tissue differentiation and development. As a protocadherin PCDH7 facilitates cell-cell interactions essential for maintaining tissue architecture.

Biological function summary

PCDH7 contributes to cell signaling and adhesion processes. It is not currently known to be a part of a large recognized complex but its interactions at the cell membrane influence cellular communication networks. In the nervous system PCDH7 supports neuronal connectivity and synaptic function aiding in the establishment of neural circuits. It also plays a part in epithelial cell layer formation aiding in maintaining proper cell alignment and barrier function. This supports PCDH7's classification as an important player in structural tissue integrity and intercellular communication.

Pathways

PCDH7 is involved in key signaling pathways that govern cellular adhesion and signaling dynamics. It plays a significant role in the Wnt signaling pathway important for cell proliferation differentiation and migration. PCDH7 interacts with proteins such as β-catenin which is a pivotal part of the Wnt pathway. Its regulation of cellular interactions helps maintain cellular structural organization ensuring normal development and response to cellular signals in specific tissues.

Associated diseases and disorders

Researchers have linked PCDH7 to respiratory disorders and certain cancers. Studies demonstrate increased expression of PCDH7 in lung adenocarcinoma indicating its potential role in tumorigenesis. It associates with proteins like E-cadherin where misregulation can lead to altered cell adhesion and metastasis. PCDH7's involvement in this dysregulation hints at its potential as a biomarker for diagnosis or a target for therapeutic interventions in cancer treatment.

Product promise

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1 product image

  • Immunocytochemistry/ Immunofluorescence - Anti-PCDH7 antibody (ab220260), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-PCDH7 antibody (ab220260)

    Immunofluorescent analysis of U-2 OS cells (PFA-fixed/Triton X-100 permeabilized) labeling PCDH7 with ab220260 at 4 μg/mL (green).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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