Anti-PCDH7 antibody [OTI2G6]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PCDH7 also known as Protocadherin 7 is a member of the protocadherin family falling under the broader cadherin superfamily. It has a mass of approximately 120 kDa. PCDH7 is a type I transmembrane protein known for its role in cellular adhesion. It is expressed in several tissues with higher expression in the nervous system and lungs. Its expression pattern suggests a role in specific tissue differentiation and development. As a protocadherin PCDH7 facilitates cell-cell interactions essential for maintaining tissue architecture.

Biological function summary

PCDH7 contributes to cell signaling and adhesion processes. It is not currently known to be a part of a large recognized complex but its interactions at the cell membrane influence cellular communication networks. In the nervous system PCDH7 supports neuronal connectivity and synaptic function aiding in the establishment of neural circuits. It also plays a part in epithelial cell layer formation aiding in maintaining proper cell alignment and barrier function. This supports PCDH7's classification as an important player in structural tissue integrity and intercellular communication.

Pathways

PCDH7 is involved in key signaling pathways that govern cellular adhesion and signaling dynamics. It plays a significant role in the Wnt signaling pathway important for cell proliferation differentiation and migration. PCDH7 interacts with proteins such as β-catenin which is a pivotal part of the Wnt pathway. Its regulation of cellular interactions helps maintain cellular structural organization ensuring normal development and response to cellular signals in specific tissues.

Associated diseases and disorders

Researchers have linked PCDH7 to respiratory disorders and certain cancers. Studies demonstrate increased expression of PCDH7 in lung adenocarcinoma indicating its potential role in tumorigenesis. It associates with proteins like E-cadherin where misregulation can lead to altered cell adhesion and metastasis. PCDH7's involvement in this dysregulation hints at its potential as a biomarker for diagnosis or a target for therapeutic interventions in cancer treatment.