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AB231152

Anti-PCDHA1 antibody

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(2 Publications)

Rabbit Polyclonal PCDHA1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PCDHA1 aa 1-250.

View Alternative Names

Protocadherin alpha-1, PCDH-alpha-1, PCDHA1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDHA1 antibody (AB231152)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDHA1 antibody (AB231152)

Formalin-fixed, paraffin-embedded human cerebrum tissue stained for PCDHA1 with ab231152 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-PCDHA1 antibody (AB231152)
  • WB

Supplier Data

Western blot - Anti-PCDHA1 antibody (AB231152)

All lanes:

Western blot - Anti-PCDHA1 antibody (ab231152) at 1 µg/mL

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Human serum

Predicted band size: 103 kDa,156 kDa,42 kDa,68 kDa

false

Western blot - Anti-PCDHA1 antibody (AB231152)
  • WB

Supplier Data

Western blot - Anti-PCDHA1 antibody (AB231152)

All lanes:

Western blot - Anti-PCDHA1 antibody (ab231152) at 2 µg/mL

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Recombinant human PCDHA1 protein

Predicted band size: 103 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PCDHA1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5I3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDHA1 also known as Protocadherin alpha-1 is a member of the protocadherin family which belong to the cadherin superfamily. This protein has a mass of approximately 105 kDa. It plays a role in forming calcium-dependent cell adhesion by binding homophilically which is important for maintaining the strength and positional accuracy of cell-cell contacts. PCDHA1 is primarily expressed in the brain particularly in the neural tissue where it contributes to the diversity and specificity of synaptic connections.
Biological function summary

PCDHA1 plays a role in the development and maintenance of neuronal networks. This protein seems to be part of a complex involved in synaptic formation and modulation. Researchers believe PCDHA1 contributes to the establishment of specific neuronal cell assemblies and supports the dynamic patterning of neuronal connectivity. The protocadherin family including PCDHA1 actively regulates the diversity of synapses required for proper neural circuit formation.

Pathways

PCDHA1 participates in the cell adhesion pathway and neural differentiation pathway. In these pathways PCDHA1 interacts with other protocadherins and likely cooperates with classical cadherins to mediate precise cellular signaling events. The target closely associates with proteins like PCDHA4 which also influences neural circuit development indicating overlapping roles across protocadherin family members in maintaining neural structure and function.

PCDHA1 has connections to neurological conditions such as autism spectrum disorders and epilepsy. Alterations in PCDHA1 expression or mutations can disrupt synaptic connectivity leading to these conditions. The protein's involvement with neurological diseases also points to its relationship with N-cadherin involved in similar pathways suggesting that these networks' proper function is essential to prevent these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
See full target information PCDHA1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Clinical breast cancer 23:397-407 PubMed36858841

2023

PCDHA1 High Expression is Associated With Poor Prognosis and Correlated With Immune Cell Infiltration in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiawei Du,Kaidi Wu

Histology and histopathology 38:1295-1306 PubMed36714978

2023

Hsa_circ_0072765 knockdown inhibits proliferation, activation and migration in transforming growth factor-beta (TGF-β)-induced hepatic stellate cells (HSCs) by the miR-197-3p/TRPV3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Jin,Xueyan Guo,Rong Zhang,Chunying Yan
View all publications
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