JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB233195

Anti-PCDHB15 antibody

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Polyclonal PCDHB15 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PCDHB15 aa 1-350.

View Alternative Names

Protocadherin beta-15, PCDH-beta-15, PCDHB15

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDHB15 antibody (AB233195)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCDHB15 antibody (AB233195)

Formalin-fixed, paraffin-embedded human kidney tissue stained for PCDHB15 using ab233195 at 20 μg/mL in immunohistochemical analysis. DAB staining.

Western blot - Anti-PCDHB15 antibody (AB233195)
  • WB

Supplier Data

Western blot - Anti-PCDHB15 antibody (AB233195)

All lanes:

Western blot - Anti-PCDHB15 antibody (ab233195) at 2 µg/mL

All lanes:

Mouse skeletal tissue lysate

Predicted band size: 86 kDa

false

Western blot - Anti-PCDHB15 antibody (AB233195)
  • WB

Supplier Data

Western blot - Anti-PCDHB15 antibody (AB233195)

All lanes:

Western blot - Anti-PCDHB15 antibody (ab233195) at 2 µg/mL

All lanes:

Recombinant human PCDHB15 protein

Predicted band size: 86 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PCDHB15 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5E8

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCDHB15 also known as Protocadherin Beta-15 is a member of the protocadherin beta gene cluster which belongs to the cadherin superfamily. This protein has a molecular weight of approximately 104 kDa. It contains multiple cadherin ectodomains serving in cell-cell adhesion primarily. PCDHB15 is expressed notably in the central nervous system particularly within the brain. Its expression contributes to the establishment and maintenance of specific neuronal connections allowing for proper synaptic signaling and neuronal circuitry.
Biological function summary

PCDHB15 plays an essential role in neuronal development and function by participating in cell adhesion and signaling processes. It forms part of a complex involved in synaptic assembly and maintenance. PCDHB15 influeces neuronal survival by promoting cell surface adhesion molecules. Additionally this protein supports synaptic stabilization through homophilic interactions with other protocadherin proteins which may ensure precise neural network formation during brain development.

Pathways

PCDHB15 interacts within the neural cadherin signaling pathway critical for synaptic plasticity and learning. It relates closely to other protocadherins and classical cadherins such as N-cadherin throughout these pathways. These associations facilitate communication between neurons and glial cells aiding the development of functional neural circuits. The adhesion function of PCDHB15 allows for dynamic regulation of synaptic contacts contributing significantly to neuroplasticity and overall cognitive function.

PCDHB15 associations indicate a connection with neurodevelopmental disorders and certain types of epilepsy. Genetic abnormalities within the PCDHB15 gene might lead to disrupted synaptic connections contributing to the pathology of these conditions. In some epilepsy forms PCDHB15 defects relate to aberrant interactions with other protocadherin proteins. Understanding the precise role of PCDHB15 can therefore provide insights into therapeutic targets for treating such neurological conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
See full target information PCDHB15
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB130751

Anti-Villin antibody [SP145]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Flow Cytometry (Intracellular) - Anti-Villin antibody [SP145] (AB130751)

  • 5
  • 5
Primary Antibodies

AB247258

Anti-ZAP70 antibody [YE291] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-ZAP70 antibody [YE291] - BSA and Azide free (AB247258)

  • 0
  • 0
Primary Antibodies

AB234744

Anti-YME1L1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-YME1L1 antibody (AB234744)

  • 0
  • 0
Primary Antibodies

AB174854

Anti-WNK1 antibody [EPR2743(3)]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-WNK1 antibody [EPR2743(3)] (AB174854)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com