Anti-PCF11 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

PCF11 influences the even regulation of gene expression by aiding in the removal of RNA polymerase II from DNA which helps in the proper conclusion of transcription. It works as part of a larger complex partnering with other factors to ensure that mRNA is properly released and processed which is important for functional mRNA maturation. These actions highlight its importance in RNA metabolism and stability.

Pathways

PCF11 is intricately involved in the transcriptional regulation pathway especially influencing the maturation of mRNA through interactions with RNA polymerase II. It closely coordinates its activities with proteins such as CTD phosphatase and SCAF8 directing the proper progression and termination of transcription. Additionally its involvement in RNA processing links it to the spliceosome-mediated mRNA decay pathway ensuring accurate gene expression control.