Anti-PCF11 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The protein PCF11 occasionally referred to as "Polypeptide Cleavage Factor 1" is an essential player in the transcription termination process. This protein serves as a component of the cleavage and polyadenylation specificity factor complex enabling the final stages of pre-mRNA synthesis. PCF11 has a molecular mass of approximately 63 kDa and is highly expressed in the nucleus where transcription occurs. It is found in many types of tissues indicating its wide-ranging roles in cellular biology.

Biological function summary

PCF11 influences the even regulation of gene expression by aiding in the removal of RNA polymerase II from DNA which helps in the proper conclusion of transcription. It works as part of a larger complex partnering with other factors to ensure that mRNA is properly released and processed which is important for functional mRNA maturation. These actions highlight its importance in RNA metabolism and stability.

Pathways

PCF11 is intricately involved in the transcriptional regulation pathway especially influencing the maturation of mRNA through interactions with RNA polymerase II. It closely coordinates its activities with proteins such as CTD phosphatase and SCAF8 directing the proper progression and termination of transcription. Additionally its involvement in RNA processing links it to the spliceosome-mediated mRNA decay pathway ensuring accurate gene expression control.

Associated diseases and disorders

Mutations and disruptions in PCF11 expression are linked to neurological disorders and various carcinomas. PCF11 anomalies can lead to defective RNA metabolism affecting neural development and cancer proliferation. In cancer it has connections with overexpressed proteins such as MYC which promotes malignant growth through misregulated transcription termination similarly impacting neurological health when dysregulated.