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AB168108

Anti-PCID2 antibody

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(1 Publication)

Rabbit Polyclonal PCID2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PCID2.

View Alternative Names

HT004, PCID2, PCI domain-containing protein 2, CSN12-like protein

1 Images
Western blot - Anti-PCID2 antibody (AB168108)
  • WB

Unknown

Western blot - Anti-PCID2 antibody (AB168108)

All lanes:

Western blot - Anti-PCID2 antibody (ab168108) at 1 µg/mL

Lane 1:

PCID2 transfected 293T cell line lysate at 15 µL

Lane 2:

Non-transfected 293T cell line lysate at 15 µL

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PCID2.

Q5JVF3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCID2 also known as PCI domain containing 2 is a protein that functions mechanically in the transport of RNA within the nucleus. It is a component of the TREX-2 complex which plays an important role in the export of mRNA from the nucleus to the cytoplasm. The protein has an approximate mass of 38 kDa. You can find PCID2 expressed in multiple tissues but its expression is higher in areas with active RNA processing such as the liver and kidneys.
Biological function summary

PCID2 interacts with other proteins as part of the TREX-2 complex to facilitate mRNA export ensuring efficient transcription and translation of genetic information. By binding to nuclear structures PCID2 links newly synthesized mRNA to the export machinery. This interaction contributes significantly to maintaining cell function cell cycle progression and viability. PCID2 also interacts with nucleoporins such as NUP153 to assist mRNA processing through the nuclear pore complexes.

Pathways

PCID2 plays an integral role in the mRNA export pathway and the general process of gene expression regulation. The protein's interaction with the TREX-2 complex highlights its importance in linking transcription to mRNA export while ensuring proper gene expression. Through these pathways PCID2 is closely related to proteins like NXF1 which mediates nuclear export as well as other members of the exon junction complex.

The dysfunction or altered regulation of PCID2 links to certain cancers and neurodegenerative diseases. Specifically disruptions in its expression or its interaction with pathway-related proteins such as NUP153 are observed in some cancer types affecting cell proliferation and tumorigenesis. Moreover its relationship with gene expression pathways suggests potential associations with conditions like amyotrophic lateral sclerosis (ALS) through interactions with proteins involved in RNA processing abnormalities.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed : 22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed : 24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity).
See full target information PCID2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Immunology 164:190-206 PubMed33987830

2021

Gm40600 promotes CD4 T-cell responses by interacting with Ahnak.

Applications

Unspecified application

Species

Unspecified reactive species

Youdi He,Ying Fang,Bing Zhai,Xiaoling Liu,Gaizhi Zhu,Shan Zhou,Yaqi Xu,Xiaoqian Wang,Wenting Su,Renxi Wang
View all publications
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