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AB154557

Anti-PCTAIRE3 antibody

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(1 Publication)

Rabbit Polyclonal PCTAIRE3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDK18 aa 150 to C-terminus.

View Alternative Names

PCTAIRE3, PCTK3, CDK18, Cyclin-dependent kinase 18, Cell division protein kinase 18, PCTAIRE-motif protein kinase 3, Serine/threonine-protein kinase PCTAIRE-3

1 Images
Western blot - Anti-PCTAIRE3 antibody (AB154557)
  • WB

Unknown

Western blot - Anti-PCTAIRE3 antibody (AB154557)

7.5% SDS PAGE

All lanes:

Western blot - Anti-PCTAIRE3 antibody (ab154557) at 1/1000 dilution

All lanes:

HepG2 whole cell lysate at 30 µg

Predicted band size: 54 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human CDK18 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q07002

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PCTAIRE3 also known as cyclin-dependent kinase 18 (CDK18) is a serine/threonine protein kinase. It has a molecular mass of approximately 37 kDa. Typically this protein is found in high amounts in the testis brain and pancreas. PCTAIRE3 plays a role in cellular processes by acting as a regulatory kinase. It is involved in phosphorylating specific substrates which is important for its function.
Biological function summary

PCTAIRE3 contributes to cell cycle regulation and neuronal signaling. It is a part of the cyclin-dependent kinase (CDK) family which is responsible for controlling progression through the cell cycle. These kinases often form complexes with cyclins to perform their regulatory roles effectively. The protein's expression in neuronal tissues suggests a role in synaptic plasticity or neuronal development though exact mechanisms need further study.

Pathways

PCTAIRE3 participates in the cell cycle and signal transduction pathways. It interacts with other CDKs and cyclins to help coordinate the cell cycle particularly in the G2/M transition. PCTAIRE3's involvement with these pathways links it to proteins like cyclin B and CDK1. Additionally its presence in signal transduction pathways connects it to various molecular signals which influence cellular responses and decisions.

Mutations or dysregulation of PCTAIRE3 have been implicated in cancers and neurodevelopmental disorders. In cancer aberrant expression of CDKs can lead to uncontrolled cell proliferation. PCTAIRE3 has been associated with specific tumors where it may interact with proteins like p53 that are critical in controlling the cell cycle and tumor suppression. In neurodevelopmental disorders variations in PCTAIRE3 might influence synaptic signaling contributing to conditions such as schizophrenia though research on these connections remains ongoing.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in signal transduction cascades in terminally differentiated cells.
See full target information CDK18
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 24:10151-10165 PubMed32715641

2020

CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Li,Dongfang Ge,Pengfei Li,Fangyong Hu,Junfeng Chu,Xiaojun Chen,Wenbo Song,Ali Wang,Guangyu Tian,Xiang Gu
View all publications
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Product promise

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