Anti-PCYOX1 antibody [EPR5611]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PCYOX1 also known as prenylcysteine oxidase 1 functions as an oxidase enzyme that specifically processes prenylated proteins by cleaving the thioether bond of prenylcysteines. This protein has a molecular weight of approximately 64 kDa. Expression of PCYOX1 is noted across various tissue types with marked presence in liver and kidney. Its localization suggests a possible involvement in cellular metabolism associated with lipid-modified proteins.

Biological function summary

The PCYOX1 protein enables degradation of prenylcysteine derivatives facilitating cellular processes related to lipid anchoring of signaling molecules. It is part of a larger complex responsible for prenylated protein turnover contributing to cellular regulation by modulating levels of signal transduction proteins anchored to membranes through prenylation.

Pathways

PCYOX1 participates in the isoprenoid metabolic pathway and is intricately linked to the post-translational modification pathway. This positions it alongside other prenylation-dependent proteins such as farnesylated and geranylgeranylated proteins which rely on similar modifications to localize to their functional membrane-bound states.

Associated diseases and disorders

Alterations in PCYOX1 activity have connections to conditions like cancer and cardiovascular diseases. Dysregulation affects protein prenylation levels impacting pathways tied to oncogenes and proteins like Ras which is often implicated in malignancies. Likewise abnormal lipid metabolism associated with PCYOX1 links to cholesterol-related cardiovascular diseases influenced by protein interactions within these pathways.