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AB84852

Anti-PDCD11 antibody [158C1a]

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Mouse Monoclonal PDCD11 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PDCD11 aa 1250-1450.

View Alternative Names

KIAA0185, PDCD11, Protein RRP5 homolog, NF-kappa-B-binding protein, Programmed cell death protein 11, NFBP

1 Images
Western blot - Anti-PDCD11 antibody [158C1a] (AB84852)
  • WB

Unknown

Western blot - Anti-PDCD11 antibody [158C1a] (AB84852)

All lanes:

Western blot - Anti-PDCD11 antibody [158C1a] (ab84852)

All lanes:

Immunogen (Recombinant Human PDCD11 fragment)

Predicted band size: 209 kDa

Observed band size: 37 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

158C1a

Isotype

IgG2a

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PDCD11 aa 1250-1450. The exact immunogen used to generate this antibody is proprietary information.

Q14690

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
ab84852 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. Filtered through a 0.22 µm membrane.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDCD11 also known as ALG-4 or HCCA2 is a nuclear protein weighing approximately 68 kDa. It is encoded by the PDCD11 gene located on chromosome 10. Researchers have observed its expression in multiple tissues with higher levels seen in lymphoid tissues and several cell lines. PDCD11 functions as a ribonucleoprotein suggesting a potential role in ribosome biogenesis and RNA processing.
Biological function summary

PDCD11 plays a role in the processing of small nucleolar RNAs (snoRNAs) and interacts as a component of ribosome biogenesis complexes. Studies indicate that it contributes to the maturation of the 18S rRNA essential for the assembly of the small ribosomal subunit. As part of the nucleolus PDCD11 assists in organizing the structure aiding the complex formation needed for efficient cellular function.

Pathways

PDCD11 integrates into genetic pathways linked with RNA processing such as transcription regulation and ribosome biogenesis frameworks. It connects with proteins like UTP6 and NOL11 within these pathways forming part of the complex machinery that coordinates the synthesis and processing of ribosomal RNA. These interactions ensure proper ribosomal assembly necessary for protein synthesis.

Researchers have linked PDCD11 to cancers such as leukemia and lymphoma. Alterations in its expression or function may disturb ribosome biogenesis influencing tumorigenesis. PDCD11's interactions with the MYC protein further highlight its potential role in oncogenic pathways where dysregulation could lead to uncontrolled cell proliferation. Understanding its involvement opens pathways for targeting ribosome biogenesis in cancer therapy.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.. Involved in the biogenesis of rRNA.
See full target information PDCD11
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Product promise

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