AB133324

Anti-PDCD2 antibody [EPR7158]

RabMAb
Recombinant
What is this?

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(4 Publications)

Rabbit Recombinant Monoclonal PDCD2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 4 publications.

View Alternative Names

RP8, ZMYND7, PDCD2, Programmed cell death protein 2, Zinc finger MYND domain-containing protein 7, Zinc finger protein Rp-8

2 Images

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Western blot - Anti-PDCD2 antibody [EPR7158] (AB133324)

All lanes:

Western blot - Anti-PDCD2 antibody [EPR7158] (ab133324) at 1/1000 dilution

Lane 1:

293T cell lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Lane 3:

Ramos cell lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 39 kDa

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OI-RD Scanning - Anti-PDCD2 antibody [EPR7158] (AB133324)

OI-RD Scanning

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OI-RD Scanning - Anti-PDCD2 antibody [EPR7158] (AB133324)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

Carrier free

Anti-PDCD2 antibody [EPR7158] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7158

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The programmed cell death protein 2 (PDCD2) plays a significant role in apoptosis also known as programmed cell death. It has alternate names such as RP8 and it is composed of approximately 38 kDa. PDCD2 expression occurs widely across various tissues which indicates a basic function in cellular processes. The protein is typically localized within the nucleus and holds a zinc finger motif that suggests its ability to interact with nucleic acids impacting gene transcription and apoptosis mechanisms.

Biological function summary

PDCD2 influences cell proliferation and apoptosis which makes it an important factor in maintaining cellular homeostasis. Researchers have identified PDCD2 as a part of the nucleosome assembly that contributes to chromatin organization. This assembly implicates PDCD2 in DNA replication and transcription regulation. By influencing these processes PDCD2 supports normal cell cycle progression affirming its importance in cellular growth and division.

Pathways

Programmed cell death and cell cycle pathways are among the significant processes involving PDCD2. It interacts with the p53 pathway an important regulator of the cell cycle and apoptosis. This interaction highlights the importance of PDCD2 in genomic stability and stress responses. PDCD2 also associates with BCL-2 family proteins which further integrates its function with apoptotic and survival pathways showcasing its role in controlling cell fate.

PDCD2 has a connection to cancer and autoimmune diseases. Its dysregulation can lead to uncontrolled cell growth frequently observed in malignancies such as leukemia. PDCD2 downregulation is associated with an increase in tumorigenic behaviors relating to its interaction with proteins like p53 that are often mutated or dysfunctional in cancers. In autoimmune disorders PDCD2 implications suggest its role in abnormal immune cell apoptosis leading to prolonged immune cell survival which contributes to pathological autoimmunity.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

See full target information PDCD2

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 7:307 PubMed34686652

2021

Effect of tumor-associated macrophages on lncRNA PURPL/miR-363/PDZD2 axis in osteosarcoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Fan He,Guoming Ding,Wu Jiang,Xiaoliang Fan,Liulong Zhu

Nucleic acids research 48:12900-12916 PubMed33245768

2020

PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2).

Applications

Unspecified application

Species

Unspecified reactive species

Anne-Marie Landry-Voyer,Danny Bergeron,Carlo Yague-Sanz,Breac Baker,Francois Bachand

Cell reports 26:3100-3115.e7 PubMed30865897

2019

An Integrated Global Analysis of Compartmentalized HRAS Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Tapesh Santra,Ana Herrero,Javier Rodriguez,Alex von Kriegsheim,Luis F Iglesias-Martinez,Thomas Schwarzl,Des Higgins,Thin-Thin Aye,Albert J R Heck,Fernando Calvo,Lorena Agudo-Ibáñez,Piero Crespo,David Matallanas,Walter Kolch

Molecular medicine reports 19:2173-2179 PubMed30664177

2019

PDCD2 sensitizes HepG2 cells to sorafenib by suppressing epithelial‑mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyu Liu,Min Wang,Na Liang,Lianyue Guan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PDCD2 antibody [EPR7158]

Western blot - Anti-PDCD2 antibody [EPR7158] (AB133324)

OI-RD Scanning - Anti-PDCD2 antibody [EPR7158] (AB133324)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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