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AB126614

Anti-PDCD2 antibody [EPR7159]

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(1 Publication)

Rabbit Recombinant Monoclonal PDCD2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

RP8, ZMYND7, PDCD2, uS5 assembly chaperone PDCD2, Programmed cell death protein 2, Zinc finger MYND domain-containing protein 7, Zinc finger protein Rp-8

1 Images
Western blot - Anti-PDCD2 antibody [EPR7159] (AB126614)
  • WB

Unknown

Western blot - Anti-PDCD2 antibody [EPR7159] (AB126614)

All lanes:

Western blot - Anti-PDCD2 antibody [EPR7159] (ab126614) at 1/1000 dilution

Lane 1:

293T cell lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-rabbit HRP at 1/2000 dilution

Predicted band size: 39 kDa

false

  • Carrier free

    Anti-PDCD2 antibody [EPR7159] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7159

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Alternative Products

Primary Antibodies

AB133324

Anti-PDCD2 antibody [EPR7158]

RabMAb|Recombinant

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  • 0
  • 0

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Primary Antibodies

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RabMAb|Recombinant|KO Validated

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Primary Antibodies

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Primary Antibodies

AB248418

Anti-DN-7 antibody [EPR5266] - BSA and Azide free

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  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The programmed cell death protein 2 (PDCD2) plays a significant role in apoptosis also known as programmed cell death. It has alternate names such as RP8 and it is composed of approximately 38 kDa. PDCD2 expression occurs widely across various tissues which indicates a basic function in cellular processes. The protein is typically localized within the nucleus and holds a zinc finger motif that suggests its ability to interact with nucleic acids impacting gene transcription and apoptosis mechanisms.
Biological function summary

PDCD2 influences cell proliferation and apoptosis which makes it an important factor in maintaining cellular homeostasis. Researchers have identified PDCD2 as a part of the nucleosome assembly that contributes to chromatin organization. This assembly implicates PDCD2 in DNA replication and transcription regulation. By influencing these processes PDCD2 supports normal cell cycle progression affirming its importance in cellular growth and division.

Pathways

Programmed cell death and cell cycle pathways are among the significant processes involving PDCD2. It interacts with the p53 pathway an important regulator of the cell cycle and apoptosis. This interaction highlights the importance of PDCD2 in genomic stability and stress responses. PDCD2 also associates with BCL-2 family proteins which further integrates its function with apoptotic and survival pathways showcasing its role in controlling cell fate.

PDCD2 has a connection to cancer and autoimmune diseases. Its dysregulation can lead to uncontrolled cell growth frequently observed in malignancies such as leukemia. PDCD2 downregulation is associated with an increase in tumorigenic behaviors relating to its interaction with proteins like p53 that are often mutated or dysfunctional in cancers. In autoimmune disorders PDCD2 implications suggest its role in abnormal immune cell apoptosis leading to prolonged immune cell survival which contributes to pathological autoimmunity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chaperone for ribosomal protein uS5; cotranslationally associates with uS5 and accompanies the ribosomal protein to assembly sites in the nucleus; appears to function redundantly to PDCD2L.
See full target information PDCD2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 10: PubMed41059573

2025

Unique epithelial proliferative transcriptomic signature in proton pump inhibitor-responsive pediatric eosinophilic esophagitis.

Applications

Unspecified application

Species

Unspecified reactive species

Somdutta Chakraborty,Ankit Sharma,Sahiti Marella,Christian F Rizza,Patrick A O'Brien,Varsha Ganesan,Gila Idelman,Susie Min,Mayee Chen,Talaya McCright-Gill,Nancy Gonzalez,Alexandros D Polydorides,Paul S Foster,Simon P Hogan,Mirna Chehade
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com