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AB229978

Anti-PDCD2L antibody

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(1 Publication)

Rabbit Polyclonal PDCD2L antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PDCD2L.

View Alternative Names

uS5 assembly chaperone PDCD2L, Programmed cell death protein 2-like, PDCD2L

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDCD2L antibody (AB229978)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDCD2L antibody (AB229978)

Paraffin-embedded human colon cancer tissue stained for PDCD2L using ab229978 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDCD2L antibody (AB229978)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDCD2L antibody (AB229978)

Paraffin-embedded human liver cancer tissue stained for PDCD2L using ab229978 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PDCD2L.

Q9BRP1

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDCD2L also known as Programmed Cell Death 2-Like protein is an important player in the regulation of apoptosis. This protein has a molecular mass of approximately 47 kDa. PDCD2L is mainly expressed in various human tissues including the liver lung and spleen. The protein demonstrates specificity in these tissues hinting at its significant role in normal cellular function. Its localized expression affects how the cells respond to stress or signals that trigger cell cycle regulation.
Biological function summary

PDCD2L contributes to programmed cell death by interacting with other apoptotic factors. It is considered to be part of the regulatory network that ensures cells undergo apoptosis when necessary. PDCD2L does not work alone; it forms part of a complex of proteins that modulate apoptotic signal transduction. Through its involvement it ensures that cells maintain a balance between survival and death making sure that damaged or unwanted cells are efficiently removed.

Pathways

PDCD2L integrates into essential apoptotic and cell cycle regulation pathways. It plays a role in the intrinsic pathway of apoptosis where it interacts with proteins such as caspases and Bcl-2 family members. In cell cycle control PDCD2L correlates with pathways associated with DNA damage response and repair influencing cellular fate based on the integrity of the genome. These pathways illustrate the protein's function in maintaining cellular homeostasis and preventing carcinogenesis by removing problematic cells.

PDCD2L has been implicated in the pathology of cancer and neurodegenerative diseases. In cancer altered expression of PDCD2L could lead to unchecked cellular proliferation and survival connecting it to proteins like p53 which is involved in tumor suppression. Neurodegenerative disorders may also link to PDCD2L through its involvement in neuronal cell death processes with proteins like tau showing relevance due to their role in cerebral dysfunction. Understanding PDCD2L in these contexts provides insights into therapeutic targets for such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.
See full target information PDCD2L
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 10: PubMed41059571

2025

AI662270/GRP94 axis couples the unfolded protein response to mitochondrial dynamics during acute myocardial infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Suling Ding,Wen Liu,Zhiwei Zhang,Xiyang Yang,Dili Sun,Jianfu Zhu,Xiaowei Zhu,Shijun Wang,Mengshi Xie,Hongyu Shi,Junbo Ge,Xiangdong Yang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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