AB126213

Anti-PDCD5 antibody

Name: Anti-PDCD5 antibody (ab126213) | Abcam
Brand: Abcam Limited
SKU: AB126213

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(3 Publications)

Rabbit Polyclonal PDCD5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDCD5 aa 1-100.

View Alternative Names

TFAR19, PDCD5, Programmed cell death protein 5, TF-1 cell apoptosis-related protein 19, Protein TFAR19

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-PDCD5 antibody (AB126213)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PDCD5 antibody (AB126213)

ab126213, at a 1/500 dilution, staining PDCD5 in methanol fixed HeLa cells by Immunofluorescence.
Image 2 (lower panel) shows costaining with Hoechst 33342.

Unknown

Western blot - Anti-PDCD5 antibody (AB126213)

15% SDS PAGE

All lanes:

Western blot - Anti-PDCD5 antibody (ab126213) at 1/1000 dilution

All lanes:

A549 whole cell lysate at 30 µg

Predicted band size: 14 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human PDCD5 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O14737

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Programmed Cell Death Protein 5 (PDCD5) also known as TFAR19 is a protein with a molecular mass of about 14 kDa. This protein is expressed widely in human tissues with high levels seen in heart liver skeletal muscle lung and pancreas. Its main role is in promoting programmed cell death or apoptosis by interacting directly with apoptotic molecules. PDCD5 translocates quickly to the nucleus in cells undergoing apoptosis indicating its direct involvement.

Biological function summary

PDCD5 assists in apoptosis by acting as an activator of this cell death mechanism. It is not part of a known protein complex but plays an essential role in enhancing the process of programmed cell death. Researchers have observed a connection between PDCD5 and p53 a well-studied tumor suppressor protein suggesting that PDCD5 may amplify p53-mediated apoptotic responses. This interaction highlights the impact of PDCD5 in cell cycle regulation and stress responses pointing to its potential as a therapeutic target in controlling abnormal cell proliferation.

Pathways

PDCD5 plays a role in apoptosis and DNA damage response pathways. It supports the p53 pathway which is important for preventing tumor formation by slowing down or stopping the cell cycle to allow DNA repair or to induce apoptosis if DNA damage is irreversible. PDCD5 may also interact with proteins like P53 promoting their apoptotic activities. Additionally through the involvement in p53 pathways PDCD5 potentially contributes to maintaining genome integrity.

PDCD5 links to cancer and neurodegenerative conditions. Its expression levels often decrease in various cancers highlighting its role in suppressing tumor growth. When PDCD5 expression is lower cells might evade apoptosis leading to tumor proliferation. In some neurodegenerative disorders altered PDCD5 function or expression has been observed suggesting its involvement in neuronal cell death. PDCD5's interaction with proteins like p53 in these conditions points to its relevance for understanding and potentially managing cancer and neurodegeneration.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May function in the process of apoptosis.

See full target information PDCD5

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature 637:983-990 PubMed39663456

2024

In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor.

Applications

Unspecified application

Species

Unspecified reactive species

Huaipeng Xing,Remus R E Rosenkranz,Piere Rodriguez-Aliaga,Ting-Ting Lee,Tomáš Majtner,Stefanie Böhm,Beata Turoňová,Judith Frydman,Martin Beck

Journal of ovarian research 17:62 PubMed38491479

2024

FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Rongli Wang,Feiyan Cheng,Xinyuan Yang

Chemical biology & drug design 96:790-800 PubMed32248621

2020

OTU deubiquitinase 5 inhibits the progression of non-small cell lung cancer via regulating p53 and PDCD5.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Yun Kang,Jing Zhang,Ling Tang,Liu Huang,Jin Tong,Qiang Fu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PDCD5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PDCD5 antibody (AB126213)

Western blot - Anti-PDCD5 antibody (AB126213)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise