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Rabbit Polyclonal PDE1A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDE1A aa 200 to C-terminus.

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Images

Western blot - Anti-PDE1A antibody (AB96336), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-PDE1A antibody (AB96336), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human PDE1A aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P54750

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBICC/IF
Human
Tested
Tested
Mouse
Predicted
Predicted
Rat
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/200.00000

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.

Alternative names

Recommended products

Rabbit Polyclonal PDE1A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDE1A aa 200 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human PDE1A aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P54750
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Phosphodiesterase 1A also known as PDE1A is a protein that breaks down cyclic nucleotides like cAMP and cGMP in cells. This enzyme belongs to the PDE family which influences cyclic nucleotide signaling. PDE1A has a molecular mass of about 61 kDa. The protein expresses widely across various tissues including the brain heart and lungs. Its activity relies on calcium/calmodulin which makes it an important player in cellular processes that involve calcium-dependent signaling.

Biological function summary

PDE1A regulates the levels of cyclic nucleotides within cells impacting signaling pathways that control various physiological responses. It does not exist as part of a larger complex but it works closely with other signaling molecules. PDE1A modulates cellular responses to external signals by controlling the degradation rate of cyclic AMP and cyclic GMP influencing functions like muscle contraction and neuronal signaling.

Pathways

PDE1A plays important roles in pathways such as the cAMP signaling pathway and the calcium signaling pathway. It interacts with proteins such as Protein Kinase A (PKA) in the cAMP pathway where it fine-tunes the cellular response to external stimuli like hormones. By regulating these pathways PDE1A helps maintain cellular homeostasis and influences how cells respond in various signaling contexts.

Associated diseases and disorders

PDE1A is linked to cardiovascular diseases and certain neurological disorders. In cardiovascular conditions abnormal PDE1A activity may contribute to uncontrolled muscle contractions and heart failure. In neurological disorders changes in PDE1A expression can disrupt normal neuronal signaling and are associated with conditions such as schizophrenia. The protein's interaction with calcium/calmodulin is critical in these conditions affecting how cells respond to signaling changes that contribute to disease development.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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2 product images

  • Western blot - Anti-PDE1A antibody (ab96336), expandable thumbnail

    Western blot - Anti-PDE1A antibody (ab96336)

    7.5% SDS-PAGE

    All lanes: Western blot - Anti-PDE1A antibody (ab96336) at 1/1000 dilution

    Lane 1: H1299 whole cell lysate at 30 µg

    Lane 2: HeLa whole cell lysate at 30 µg

    Predicted band size: 61 kDa

  • Immunocytochemistry/ Immunofluorescence - Anti-PDE1A antibody (ab96336), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-PDE1A antibody (ab96336)

    ab96336, at a 1/200 dilution, staining PDE1A in paraformaldehyde fixed HeLa by Immunofluorescence.
    Lower image is merged with DNA probe.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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