Rabbit Polyclonal PDE1A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDE1A aa 200 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Mouse | Predicted | Predicted |
Rat | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/200.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Select an associated product type
Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.
Cam-PDE 1A, 61 kDa Cam-PDE, hCam-1, PDE1A
Rabbit Polyclonal PDE1A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDE1A aa 200 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
Phosphodiesterase 1A also known as PDE1A is a protein that breaks down cyclic nucleotides like cAMP and cGMP in cells. This enzyme belongs to the PDE family which influences cyclic nucleotide signaling. PDE1A has a molecular mass of about 61 kDa. The protein expresses widely across various tissues including the brain heart and lungs. Its activity relies on calcium/calmodulin which makes it an important player in cellular processes that involve calcium-dependent signaling.
PDE1A regulates the levels of cyclic nucleotides within cells impacting signaling pathways that control various physiological responses. It does not exist as part of a larger complex but it works closely with other signaling molecules. PDE1A modulates cellular responses to external signals by controlling the degradation rate of cyclic AMP and cyclic GMP influencing functions like muscle contraction and neuronal signaling.
PDE1A plays important roles in pathways such as the cAMP signaling pathway and the calcium signaling pathway. It interacts with proteins such as Protein Kinase A (PKA) in the cAMP pathway where it fine-tunes the cellular response to external stimuli like hormones. By regulating these pathways PDE1A helps maintain cellular homeostasis and influences how cells respond in various signaling contexts.
PDE1A is linked to cardiovascular diseases and certain neurological disorders. In cardiovascular conditions abnormal PDE1A activity may contribute to uncontrolled muscle contractions and heart failure. In neurological disorders changes in PDE1A expression can disrupt normal neuronal signaling and are associated with conditions such as schizophrenia. The protein's interaction with calcium/calmodulin is critical in these conditions affecting how cells respond to signaling changes that contribute to disease development.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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7.5% SDS-PAGE
All lanes: Western blot - Anti-PDE1A antibody (ab96336) at 1/1000 dilution
Lane 1: H1299 whole cell lysate at 30 µg
Lane 2: HeLa whole cell lysate at 30 µg
Predicted band size: 61 kDa
ab96336, at a 1/200 dilution, staining PDE1A in paraformaldehyde fixed HeLa by Immunofluorescence.
Lower image is merged with DNA probe.
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