Rabbit Polyclonal PDE1C/PDE1 antibody. Suitable for IP, WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 7 publications.
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Publications
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- Circulation research 129:872-8862021PDE1 Inhibition Modulates Ca1.2 Channel to Stimulate Cardiomyocyte Contraction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGrace K Muller,Joy Song,Vivek Jani,Yuejin Wu,Ting Liu,William P D Jeffreys,Brian O'Rourke,Mark E Anderson,David A KassPubMed 34521216
- Archives of biochemistry and biophysics 662:160-1682018Phosphodiesterase expression in the normal and failing heart.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEdwin A Li,Wang Xi,Young Soo Han,Frank V BrozovichPubMed 30550727
- Journal of the American Society of Nephrology : JASN 27:1124-342015Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCibele S Pinto,Archana Raman,Gail A Reif,Brenda S Magenheimer,Corey White,James P Calvet,Darren P WallacePubMed 26289612
- The European journal of neuroscience 36:2452-602012Postnatal experience modulates functional properties of mouse olfactory sensory neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiwei He et. al.PubMed 22703547
- The Journal of neuroscience : the official journal of the Society for Neuroscience 31:2974-822011Olfactory marker protein is critical for functional maturation of olfactory sensory neurons and development of mother preference.
- Hypertension (Dallas, Tex. : 1979) 57:655-632011Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1.
- Kidney international 77:129-402009Cyclic nucleotide signaling in polycystic kidney disease.Applications:IHC-PReactive species:Mouse, RatXiaofang Wang,Christopher J Ward,Peter C Harris,Vicente E TorresPubMed 19924104
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
- Standard buffer
- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IP | WB | IHC-P | |
|---|---|---|---|
| Human | Expected | Predicted | Expected |
| Mouse | Expected | Predicted | Expected |
| Rat | Expected | Tested | Expected |
IP
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info Use at an assay dependent concentration. | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/250.00000 - 1/500.00000 | Notes This antibody labels multiple bands in the 70-87 kDa range all believed to be various PDE1C variants. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse | Dilution info - | Notes - |
IHC-P
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info Use at an assay dependent concentration. | Notes - |
Target data
Function
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
Alternative names
Cam-PDE 1C, Hcam3, PDE1C
Recommended products
Rabbit Polyclonal PDE1C/PDE1 antibody. Suitable for IP, WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 7 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
- Standard buffer
- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Specificity
The antibody does not cross react with PDE1A, PDE1B or other PDEs.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PDE1C also known as phosphodiesterase 1C is an enzyme that mechanically regulates intracellular levels of cyclic nucleotides by hydrolyzing cAMP and cGMP. It has a mass of approximately 85 kDa. You can find PDE1C expression in various tissues including the brain heart and vascular smooth muscle. This expression pattern shows its importance in diverse physiological contexts where cAMP and cGMP act as second messengers.
- Biological function summary
PDE1C functions as a calcium/calmodulin-dependent phosphodiesterase integrating signals where calcium levels fluctuate. It belongs to a larger family of phosphodiesterases that help modulate intracellular signaling pathways through cyclic nucleotide metabolism. This enzyme can operate independently or as part of complexes with other proteins which allows it to finely tune cellular response to external stimuli by adjusting cAMP and cGMP concentrations.
- Pathways
PDE1C plays a significant role in key biological processes related to cyclic nucleotide signaling. It is particularly important in the regulation of the cardiovascular system by affecting vasodilation and cardiac contractility through pathways involving cAMP and cGMP. The enzyme is also involved in the smooth muscle relaxation pathway. PDE1C also interacts with calcium-dependent pathways to coordinate cellular responses that involve isoforms of proteins like PKG (cGMP-dependent protein kinase) and PKA (cAMP-dependent protein kinase).
- Associated diseases and disorders
Aberrant activity of PDE1C links to conditions such as cardiovascular diseases and certain cancers. Dysregulated expression of PDE1C can alter smooth muscle function and contribute to disorders like hypertension and cardiac hypertrophy. PDE1C also interacts with proteins like VEGF (vascular endothelial growth factor) in cancer biology where it can influence tumor growth and angiogenesis by modifying cellular proliferation through altered cyclic nucleotide signaling.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-PDE1C/PDE1 antibody (ab14602)
Western Blot analysis of PDE1C/PDE1 with ab14602 (1/500). Rat tissues: 1- Brain; 2 -Heart; 3 - Lung; 4 - Testis; 5 - Kidney.
All lanes: Western blot - Anti-PDE1C/PDE1 antibody (ab14602) at 1/500 dilution
Lane 1: Brain lysate
Lane 2: Heart lysate
Lane 3: Lung lysate
Lane 4: Testis lysate
Lane 5: Kidney lysate
Predicted band size: 81 kDa
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