AB14602

Anti-PDE1C/PDE1 antibody

Name: Anti-PDE1C/PDE1 antibody (ab14602) | Abcam
Brand: Abcam Limited
SKU: AB14602

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(9 Publications)

Rabbit Polyclonal PDE1C/PDE1 antibody. Suitable for IP, WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 9 publications.

View Alternative Names

Cam-PDE 1C, Hcam3, PDE1C

1 Images

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Western blot - Anti-PDE1C/PDE1 antibody (AB14602)

Western Blot analysis of PDE1C/PDE1 with ab14602 (1/500). Rat tissues : 1- Brain; 2 -Heart; 3 - Lung; 4 - Testis; 5 - Kidney.

All lanes:

Western blot - Anti-PDE1C/PDE1 antibody (ab14602) at 1/500 dilution

Lane 1:

Brain lysate

Lane 2:

Heart lysate

Lane 3:

Lung lysate

Lane 4:

Testis lysate

Lane 5:

Kidney lysate

Predicted band size: 81 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human, Mouse

Applications

WB, IHC-P, IP

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

The antibody does not cross react with PDE1A, PDE1B or other PDEs.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/250 - 1/500", "WB-species-notes": "This antibody labels multiple bands in the 70-87 kDa range all believed to be various PDE1C variants.", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDE1C also known as phosphodiesterase 1C is an enzyme that mechanically regulates intracellular levels of cyclic nucleotides by hydrolyzing cAMP and cGMP. It has a mass of approximately 85 kDa. You can find PDE1C expression in various tissues including the brain heart and vascular smooth muscle. This expression pattern shows its importance in diverse physiological contexts where cAMP and cGMP act as second messengers.

Biological function summary

PDE1C functions as a calcium/calmodulin-dependent phosphodiesterase integrating signals where calcium levels fluctuate. It belongs to a larger family of phosphodiesterases that help modulate intracellular signaling pathways through cyclic nucleotide metabolism. This enzyme can operate independently or as part of complexes with other proteins which allows it to finely tune cellular response to external stimuli by adjusting cAMP and cGMP concentrations.

Pathways

PDE1C plays a significant role in key biological processes related to cyclic nucleotide signaling. It is particularly important in the regulation of the cardiovascular system by affecting vasodilation and cardiac contractility through pathways involving cAMP and cGMP. The enzyme is also involved in the smooth muscle relaxation pathway. PDE1C also interacts with calcium-dependent pathways to coordinate cellular responses that involve isoforms of proteins like PKG (cGMP-dependent protein kinase) and PKA (cAMP-dependent protein kinase).

Aberrant activity of PDE1C links to conditions such as cardiovascular diseases and certain cancers. Dysregulated expression of PDE1C can alter smooth muscle function and contribute to disorders like hypertension and cardiac hypertrophy. PDE1C also interacts with proteins like VEGF (vascular endothelial growth factor) in cancer biology where it can influence tumor growth and angiogenesis by modifying cellular proliferation through altered cyclic nucleotide signaling.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed : 29860631, PubMed : 8557689). Has a high affinity for both cAMP and cGMP (PubMed : 8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).

See full target information PDE1C

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 83:2889-2907 PubMed37335130

2023

Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Debarati Mukherjee,Rebecca A Previs,Corinne Haines,Muthana Al Abo,Patrick K Juras,Kyle C Strickland,Binita Chakraborty,Sandeep Artham,Regina S Whitaker,Katherine Hebert,Jake Fontenot,Steven R Patierno,Jennifer A Freedman,Frank H Lau,Matthew E Burow,Ching-Yi Chang,Donald P McDonnell

Frontiers in genetics 13:686739 PubMed35601482

2022

Single-Cell Transcriptomics Uncovers Cellular Heterogeneity, Mechanisms, and Therapeutic Targets for Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjun Huang,Li Liu,Lingling Qin,Hehua Huang,Xue Li

Circulation research 129:872-886 PubMed34521216

2021

PDE1 Inhibition Modulates Ca1.2 Channel to Stimulate Cardiomyocyte Contraction.

Applications

Unspecified application

Species

Unspecified reactive species

Grace K Muller,Joy Song,Vivek Jani,Yuejin Wu,Ting Liu,William P D Jeffreys,Brian O'Rourke,Mark E Anderson,David A Kass

Archives of biochemistry and biophysics 662:160-168 PubMed30550727

2018

Phosphodiesterase expression in the normal and failing heart.

Applications

Unspecified application

Species

Unspecified reactive species

Edwin A Li,Wang Xi,Young Soo Han,Frank V Brozovich

Journal of the American Society of Nephrology : JASN 27:1124-34 PubMed26289612

2015

Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Cibele S Pinto,Archana Raman,Gail A Reif,Brenda S Magenheimer,Corey White,James P Calvet,Darren P Wallace

The European journal of neuroscience 36:2452-60 PubMed22703547

2012

Postnatal experience modulates functional properties of mouse olfactory sensory neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jiwei He,Huikai Tian,Anderson C Lee,Minghong Ma

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:2974-82 PubMed21414919

2011

Olfactory marker protein is critical for functional maturation of olfactory sensory neurons and development of mother preference.

Applications

Species

Mouse

Anderson C Lee,Jiwei He,Minghong Ma

Hypertension (Dallas, Tex. : 1979) 57:655-63 PubMed21282562

2011

Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1.

Applications

Species

Rat

Fernanda R Giachini,Victor V Lima,Fernando S Carneiro,Rita C Tostes,R Clinton Webb

Kidney international 77:129-40 PubMed19924104

2009

Cyclic nucleotide signaling in polycystic kidney disease.

Applications

IHC-P, IHC-P

Species

Mouse, Rat

Xiaofang Wang,Christopher J Ward,Peter C Harris,Vicente E Torres

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-PDE1C/PDE1 antibody

Western blot - Anti-PDE1C/PDE1 antibody (AB14602)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise