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AB42091

Anti-PDE3B antibody

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(3 Publications)

Goat Polyclonal PDE3B antibody. Suitable for WB and reacts with Recombinant full length protein - Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PDE3B aa 1050 to C-terminus.

View Alternative Names

CGIPDE1, Cyclic GMP-inhibited phosphodiesterase B, CGIP1, CGI-PDE B, PDE3B

1 Images
Western blot - Anti-PDE3B antibody (AB42091)
  • WB

Supplier Data

Western blot - Anti-PDE3B antibody (AB42091)

All lanes:

Western blot - Anti-PDE3B antibody (ab42091) at 1/500 dilution

All lanes:

Human PDE3B protein

Predicted band size: 124 kDa

Observed band size: 145 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PDE3B aa 1050 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q13370

Specificity

Does not cross react with PDE4A variants nor with any other PDEs.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 6 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDE3B also known as cGMP-inhibited phosphodiesterase B is an enzyme with a role in cyclic nucleotide signaling. It possesses a molecular mass of approximately 133 kDa. PDE3B predominantly gets expressed in adipose tissue liver and to some extent in the heart. It breaks down cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which play key roles in cellular signaling. By hydrolyzing these cyclic nucleotides into their non-cyclic forms PDE3B regulates intracellular levels of these molecules.
Biological function summary

In adipose tissue and liver PDE3B modulates lipogenesis and lipolysis which are vital processes for energy balance. This enzyme interacts with signaling pathways that involve protein kinase A (PKA) and insulin signaling. PDE3B operates as part of larger protein complexes and influences the metabolic rate by regulating the availability of the cAMP for phosphorylation reactions. The activity of PDE3B links closely to the control of energy homeostasis due to its regulatory function on lipid metabolism.

Pathways

PDE3B is integral to the insulin signaling pathway and adiponectin signaling pathway both important in glucose and lipid homeostasis. Within these pathways it functions alongside proteins like AKT and PKA where its activity modulates their signaling efficiency. By controlling the balance of cAMP PDE3B influences signaling cascades that are important for the adaptive cellular responses to hormones and nutrients.

PDE3B connects to conditions such as obesity and type 2 diabetes due to its involvement in energy homeostasis and lipid metabolism. In type 2 diabetes the dysregulation of PDE3B activity affects insulin signaling and glucose uptake. Additionally in the context of obesity PDE3B activity shifts the balance of lipolysis and lipogenesis influencing adipose tissue mass and function. Proteins such as insulin receptors and PKA become closely tied to PDE3B in these disorders highlighting its role in metabolic disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed : 14592490, PubMed : 21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed : 21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity).
See full target information PDE3B
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Marine drugs 19: PubMed33805447

2021

Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chih-Hung Guo,Simon Hsia,Chieh-Han Chung,Yi-Chun Lin,Min-Yi Shih,Pei-Chung Chen,Guoo-Shyng W Hsu,Ciou-Ting Fan,Chia-Lin Peng

PloS one 14:e0214606 PubMed30990811

2019

PID1 alters the antilipolytic action of insulin and increases lipolysis via inhibition of AKT/PKA pathway activation.

Applications

Unspecified application

Species

Unspecified reactive species

Chunyan Yin,Wei Hua Liu,Yuesheng Liu,Li Wang,Yanfeng Xiao

International journal of medical sciences 15:1194-1202 PubMed30123057

2018

Effects of Chinese Medicinal Formula BNG-1 on Phosphodiesterase 3B Expression, Hepatic Steatosis, and Insulin Resistance in High Fat Diet-induced NAFLD Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chih-Hung Guo,Wen-Long Chen,Chung-Huei Liao,Karin Huang,Pei-Yin Chen,Chun-Pai Yang
View all publications
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