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AB42094

Anti-PDE4A antibody

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(3 Publications)

Rabbit Polyclonal PDE4A antibody. Suitable for WB and reacts with Recombinant fragment samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Rat Pde4a.

View Alternative Names

DPDE2, cAMP-specific phosphodiesterase 4A, Pde4a

1 Images
Western blot - Anti-PDE4A antibody (AB42094)
  • WB

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Western blot - Anti-PDE4A antibody (AB42094)

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Western blot - Anti-PDE4A antibody (ab42094)

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PDE4A5

Predicted band size: 98 kDa

Observed band size: 108 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

WB

applications

Immunogen

Synthetic Peptide within Rat Pde4a. The exact immunogen used to generate this antibody is proprietary information.

P54748

Specificity

PDE4A5 variant specific. Does not cross-react with PDE4A8 or other PDE4A proteins including PDE4A4, PDE4A1 and PDE4Ax or with other PDE family members.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 6 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDE4A or phosphodiesterase 4A is an isoform part of the PDE4 family known for hydrolyzing cAMP an important second messenger in cells. The mass of PDE4A can vary depending on the isoform with commonly referenced masses around 70-100 kDa. This enzyme is expressed in various tissues including the brain immune cells and lungs. Other popular names for this protein include PDE46 and DPDE2 indicating its different isoforms and specific functionalities across tissue types.
Biological function summary

PDE4A plays an important role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) a critical component in signaling pathways that affect numerous cellular processes. By controlling cAMP concentrations PDE4A regulates inflammatory responses and airway smooth muscle contraction which is important for respiratory functions. PDE4A does not function within a complex but operates as a homodimer when exerting its effects on signaling cascades.

Pathways

PDE4A's role is significant in the cAMP-dependent signaling pathway. This pathway influences processes like inflammation and smooth muscle relaxation. PDE4A interacts with various proteins such as PKA (protein kinase A) which is activated by cAMP and mediates several downstream effects. By influencing the cAMP pathway PDE4A affects bodily responses including immune and respiratory systems.

PDE4A has implications in conditions such as asthma and chronic obstructive pulmonary disease (COPD). Dysregulation of cAMP through PDE4A can contribute to these respiratory conditions by affecting airway inflammation and muscle tone. PDE4A is also linked to other related proteins such as PDE4B which can also impact inflammatory pathways in similar disease contexts. PDE4 inhibitors have been explored as therapeutic agents for modifying these diseases by targeting the enzymatic activity of PDE4A and related isoforms to restore balanced cAMP levels.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes.. Isoform 1. Efficiently hydrolyzes cAMP.. Isoform 2. Efficiently hydrolyzes cAMP.
See full target information Pde4a
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 26:2805-2817.e9 PubMed30840899

2019

Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Marie Katrancha,Juliana E Shaw,Amy Y Zhao,Samuel A Myers,Alexandra R Cocco,Amanda T Jeng,Minsheng Zhu,Christopher Pittenger,Charles A Greer,Steven A Carr,Xiao Xiao,Anthony J Koleske

Frontiers in systems neuroscience 10:5 PubMed26903822

2016

Traumatic Brain Injury Upregulates Phosphodiesterase Expression in the Hippocampus.

Applications

WB

Species

Unspecified reactive species

Nicole M Wilson,David J Titus,Anthony A Oliva,Concepcion Furones,Coleen M Atkins

Journal of neurochemistry 123:1019-29 PubMed23057870

2012

Phosphodiesterase isoform-specific expression induced by traumatic brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Anthony A Oliva,Yuan Kang,Concepcion Furones,Ofelia F Alonso,Olga Bruno,W Dalton Dietrich,Coleen M Atkins
View all publications
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