AB171749

Anti-PDE4D antibody [EPR11823-29]

RabMAb
Recombinant
What is this?

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(3 Publications)

Rabbit Recombinant Monoclonal PDE4D antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

DPDE3, PDE4D, PDE43, cAMP-specific phosphodiesterase 4D

1 Images

Supplier Data

Western blot - Anti-PDE4D antibody [EPR11823-29] (AB171749)

All lanes:

Anti-cardiac Troponin I antibody (<a href='/en-us/products/unavailable/cardiac-troponin-i-antibody-ab1000'>ab1000</a>) at 1/171749 dilution

Lane 1:

Human fetal heart lysate at 10 µg

Lane 2:

Human fetal brain lysate at 10 µg

Lane 3:

K562 cell lysate at 10 µg

Predicted band size: 91 kDa

false

Carrier free

Anti-PDE4D antibody [EPR11823-29] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11823-29

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Phosphodiesterase 4D (PDE4D) is an enzyme that hydrolyzes cyclic AMP (cAMP) to its inactive form AMP controlling important cellular signaling pathways. It is part of the large PDE family and sometimes referred to as DPDE1. With a molecular weight of approximately 93 kDa PDE4D is widely expressed in the brain heart lungs and immune cells. Its expression in these tissues indicates an important regulatory role in both central and peripheral physiological processes.

Biological function summary

PDE4D plays an important role in the modulation of intracellular cAMP levels impacting processes such as inflammation cognition and cardiac function. It does not operate as part of a larger complex but collaborates with other signaling molecules to influence cellular responses. PDE4D's regulation of cAMP levels directly affects protein kinase A (PKA) leading to alterations in gene expression and cell activity.

Pathways

PDE4D integrates into the cAMP signaling and inflammatory pathways impacting various cellular responses. In the cAMP signaling pathway it partners with other PDEs and signaling proteins such as PKA which phosphorylates target proteins affecting cellular function. In inflammatory pathways PDE4D modulates immune cell activity by altering the cAMP-mediated inhibition of pro-inflammatory cytokine production linking it to inflammation-related responses.

PDE4D has associations with conditions such as asthma and ischemic stroke. In asthma PDE4D regulates cAMP levels in lung cells affecting bronchial constriction and inflammation. In ischemic stroke alterations in PDE4D activity influence vascular function by changing cAMP dynamics in vascular smooth muscle cells. Within these disorders PDE4D interacts with proteins like cytokines and COX-2 which also play parts in inflammatory pathways and vascular responses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

See full target information PDE4D

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 292:3360-3377 PubMed39673076

2024

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Yan Sin,Aoife Giblin,Aleksandra Judina,Punchita Rujirachaivej,Laura G Corral,Eliza Glennon,Zhi Xian Tai,Tian Feng,Eduardo Torres,Alina Zorn,Julia Gorelik,Elka Kyurkchieva,Pa Thai Yenchitsomanus,Cathy Swindlehurst,Kyle Chan,David Stirling,George S Baillie

Cellular and molecular life sciences : CMLS 80:178 PubMed37306762

2023

Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology.

Applications

Unspecified application

Species

Unspecified reactive species

Dean Paes,Melissa Schepers,Emily Willems,Ben Rombaut,Assia Tiane,Yevgeniya Solomina,Amy Tibbo,Connor Blair,Elka Kyurkchieva,George S Baillie,Roberta Ricciarelli,Chiara Brullo,Ernesto Fedele,Olga Bruno,Daniel van den Hove,Tim Vanmierlo,Jos Prickaerts

Diagnostics (Basel, Switzerland) 11: PubMed34063765

2021

Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence.

Applications

Unspecified application

Species

Unspecified reactive species

Ombretta Repetto,Federica Lovisa,Caterina Elia,Daniel Enderle,Filippo Romanato,Salvatore Buffardi,Alessandra Sala,Marta Pillon,Agostino Steffan,Roberta Burnelli,Lara Mussolin,Maurizio Mascarin,Valli De Re

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PDE4D antibody [EPR11823-29]

Western blot - Anti-PDE4D antibody [EPR11823-29] (AB171749)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise