Anti-PDE4D3 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

PDE4D3 participates in the modulation of intracellular signaling through the breakdown of cAMP. It is not part of a classical complex but closely interacts with other signaling molecules to perform its functions. This activity impacts processes such as inflammation mood regulation and airway muscle contraction. By controlling cAMP levels PDE4D3 plays a role in the appropriate response of cells to external stimuli thereby influencing cellular responses such as proliferation and differentiation.

Pathways

PDE4D3 is part of the cAMP signaling pathway a fundamental pathway impacting processes like smooth muscle relaxation and immune response regulation. It regulates the activity of protein kinase A (PKA) by controlling cAMP levels which in turn influences other proteins involved in these pathways. Another pathway involving PDE4D3 includes the mitogen-activated protein kinase (MAPK) pathway contributing to cellular responses to growth factors. PDE4D3 interacts with proteins such as β-arrestins which mediate receptor signaling and internalization linking cAMP breakdown to broad cellular effects.