Anti-PDE4D3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PDE4D3 also known as the phosphodiesterase 4D cAMP-specific 3 isoform plays a mechanical role in the hydrolysis of cyclic AMP (cAMP) to AMP. It possesses a molecular mass of approximately 90 kDa. This protein is well-expressed in various tissues including the brain lungs and heart highlighting its significance in several physiological processes. The enzyme belongs to the PDE4 family that is important for the regulation of cellular levels of cAMP a secondary messenger involved in numerous signal transduction pathways.

Biological function summary

PDE4D3 participates in the modulation of intracellular signaling through the breakdown of cAMP. It is not part of a classical complex but closely interacts with other signaling molecules to perform its functions. This activity impacts processes such as inflammation mood regulation and airway muscle contraction. By controlling cAMP levels PDE4D3 plays a role in the appropriate response of cells to external stimuli thereby influencing cellular responses such as proliferation and differentiation.

Pathways

PDE4D3 is part of the cAMP signaling pathway a fundamental pathway impacting processes like smooth muscle relaxation and immune response regulation. It regulates the activity of protein kinase A (PKA) by controlling cAMP levels which in turn influences other proteins involved in these pathways. Another pathway involving PDE4D3 includes the mitogen-activated protein kinase (MAPK) pathway contributing to cellular responses to growth factors. PDE4D3 interacts with proteins such as β-arrestins which mediate receptor signaling and internalization linking cAMP breakdown to broad cellular effects.

Associated diseases and disorders

PDE4D3 has associations with asthma and depression. In asthma altered control of cAMP levels can lead to improper relaxation of airway muscles causing symptoms associated with the disease. In depression aberrant cAMP signaling is linked to mood regulation issues with PDE4D3 as a target for potential treatment. This target interacts with serotonin receptors which play roles in mood stabilization connecting PDE4D3 to the modulation of serotonin levels and signaling relevant in depression therapy strategies.