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AB121275

Anti-PDE4DIP antibody

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(1 Publication)

Rabbit Polyclonal PDE4DIP antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDE4DIP aa 500-700.

View Alternative Names

CMYA2, KIAA0454, KIAA0477, MMGL, PDE4DIP, Myomegalin, Cardiomyopathy-associated protein 2, Phosphodiesterase 4D-interacting protein

2 Images
Western blot - Anti-PDE4DIP antibody (AB121275)
  • WB

Supplier Data

Western blot - Anti-PDE4DIP antibody (AB121275)

All lanes:

Western blot - Anti-PDE4DIP antibody (ab121275) at 0.4 µg/mL

Lane 1:

U-251 MG (formally U-373 MG) (human brain glioma cell line) whole cell lysate

Lane 2:

A549 (human lung carcinoma cell line) whole cell lysate

Predicted band size: 265 kDa

false

Western blot - Anti-PDE4DIP antibody (AB121275)
  • WB

Supplier Data

Western blot - Anti-PDE4DIP antibody (AB121275)

All lanes:

Western blot - Anti-PDE4DIP antibody (ab121275) at 0.4 µg/mL

Lane 1:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate

Lane 2:

NBT-II (rat urinary bladder tumor cell line) whole cell lysate

Predicted band size: 265 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PDE4DIP aa 500-700. The exact immunogen used to generate this antibody is proprietary information.

Q5VU43

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDE4DIP also known as Myomegalin is a large protein with a molecular weight of approximately 260 kDa. This protein is mainly expressed in heart and brain tissues. PDE4DIP interacts with phosphodiesterase 4D targeting it to specific intracellular sites which is key for its mechanical functions. The interactions help maintain proper localization and function of phosphodiesterase 4D which plays a role in cAMP signaling processes.
Biological function summary

The role of PDE4DIP extends to its involvement in cellular scaffolding. As part of the centrosomal complex it influences the organization of microtubules which affects cell division and intracellular transport. The presence of PDE4DIP in heart and brain tissues aligns with its biological functions where precise cellular organization is necessary for maintaining proper cellular responses and operations in these organs.

Pathways

PDE4DIP’s involvement in cAMP signaling and microtubule dynamics positions it in key regulatory pathways. The protein interacts with phosphodiesterase 4D playing an important role in the modulation of cAMP levels which affects signaling pathways such as the PKA signaling pathway. Additionally the connection of PDE4DIP with microtubule-associated proteins situates it within the pathway governing cell structure and motility.

The aberrant expression or mutation of PDE4DIP has links to cardiac hypertrophy and neurodegenerative diseases. For cardiac hypertrophy the interaction with phosphodiesterase 4D influences signal pathways related to heart muscle cell growth. In neurodegenerative diseases such as Alzheimer's disease PDE4DIP’s role in microtubule dynamics and intracellular transport can affect neuronal structure and function possibly involving proteins connected to neurofibrillary tangles like tau protein.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).. Isoform 13. Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed : 25217626, PubMed : 27666745, PubMed : 28814570, PubMed : 29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed : 27666745, PubMed : 28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed : 29162697).
See full target information PDE4DIP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of nanomedicine 19:2071-2090 PubMed38476275

2024

MSC-Derived Exosomes Mitigate Myocardial Ischemia/Reperfusion Injury by Reducing Neutrophil Infiltration and the Formation of Neutrophil Extracellular Traps.

Applications

Unspecified application

Species

Unspecified reactive species

Yuting Feng,Xue Bao,Jinxuan Zhao,Lina Kang,Xuan Sun,Biao Xu
View all publications
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Product promise

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