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Rabbit Recombinant Monoclonal PDGFC antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

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Images

Sandwich ELISA - Anti-PDGF CC antibody [EPR21022-28] - BSA and Azide free (Capture) (AB244756), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

Constituents: 100% PBS

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
sELISA
Human
Expected

Expected
Expected

Species
Human
Dilution info
Use at an assay dependent concentration.
Notes

-

Target data

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

Alternative names

SCDGF, UNQ174/PRO200, PDGFC, Platelet-derived growth factor C, PDGF-C, Fallotein, Spinal cord-derived growth factor, VEGF-E

Recommended products

Rabbit Recombinant Monoclonal PDGFC antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Carrier free
Yes
Clone number
EPR21022-28
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C

Notes

ab244756 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human PDGF-CC. The recommended pair for sandwich ELISA is:
Capture: ab244756, Human PDGF-CC Capture Antibody (unconjugated)
Detector: Anti-PDGF CC antibody [EPR21022-117] - BSA and Azide free (Detector) ab245026, Human PDGF-CC Detector Antibody (unconjugated)
The reference range value is 28.125 - 1800 pg/ml.

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Platelet-Derived Growth Factor CC (PDGF-CC) is a member of the PDGF family consisting of homodimeric and heterodimeric isoforms. PDGF-CC with a mass of approximately 44 kDa partakes in various cellular processes. It primarily expresses in fibroblasts endothelial cells and some types of neurons. PDGF-CC functions by binding to tyrosine kinase receptors specifically PDGFRαα and PDGFRαβ where it triggers intracellular signaling pathways.

Biological function summary

PDGF-CC influences cell proliferation migration and survival particularly in the context of vascular development and remodeling. It acts as a powerful growth factor for mesenchymal cells and plays a role in embryonic development. PDGF-CC forms a functional complex after proteolytic activation which is essential for its receptor-binding capacity. This factor significantly regulates angiogenesis and wound healing processes.

Pathways

PDGF-CC is integral to the PDGF signaling pathway and is involved in the PI3K/AKT signaling pathway. These pathways promote cellular growth survival and proliferation. PDGF-CC's interaction with PDGF receptors primarily PDGFRα facilitates these biological functions. In these pathways PDGF-CC interacts with other proteins such as PI3K and AKT connecting it to broader cellular response networks.

Associated diseases and disorders

PDGF-CC has been associated with fibrotic diseases and certain cancers. Its overexpression or dysregulation can contribute to pathological fibrosis through excessive tissue repair. PDGF-CC is also linked to glioblastoma a type of brain cancer where abnormal PDGF signaling leads to tumor progression. PDGF-CC interacts with PDGFRα in these disease contexts highlighting its contribution to disease mechanisms when dysregulated.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Sandwich ELISA - Anti-PDGF CC antibody [EPR21022-28] - BSA and Azide free (Capture) (ab244756), expandable thumbnail

    Sandwich ELISA - Anti-PDGF CC antibody [EPR21022-28] - BSA and Azide free (Capture) (ab244756)

    Representative standard curve from corresponding SimpleStep ELISA® Kit (Human PDGF-CC ELISA Kit ab234568).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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